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MedKoo Cat#: 573581 | Name: alpha-Clopenthixol HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

alpha-Clopenthixol is a thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors.

Chemical Structure

alpha-Clopenthixol HCl
alpha-Clopenthixol HCl
CAS#633-59-0 (HCl)

Theoretical Analysis

MedKoo Cat#: 573581

Name: alpha-Clopenthixol HCl

CAS#: 633-59-0 (HCl)

Chemical Formula: C22H27Cl3N2OS

Exact Mass: 472.0910

Molecular Weight: 473.88

Elemental Analysis: C, 55.76; H, 5.74; Cl, 22.44; N, 5.91; O, 3.38; S, 6.77

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
633-59-0 (HCl) 982-24-1 (free base)
Synonym
alpha-Clopenthixol dihydrochloride; AY 62021; AY62021; AY-62021; Ciatyl; Clopenthixol dihydrochloride; N 746; N-746; N746; Sordenac; α-Clopenthixol dihydrochloride;
IUPAC/Chemical Name
1-Piperazineethanol, 4-(3-(2-chloro-9H-thioxanthen-9-ylidene)propyl)-, dihydrochloride (9CI)
InChi Key
LPWNZMIBFHMYMX-MHKBYHAFSA-N
InChi Code
1S/C22H25ClN2OS.2ClH/c23-17-7-8-22-20(16-17)18(19-4-1-2-6-21(19)27-22)5-3-9-24-10-12-25(13-11-24)14-15-26;;/h1-2,4-8,16,26H,3,9-15H2;2*1H/b18-5-
SMILES Code
c1ccc2c(c1)/C(=C/CCN3CCN(CC3)CCO)/c4cc(ccc4S2)Cl.Cl.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 473.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Aaes-Jørgensen T, Gravem A, Jørgensen A. Serum levels of the isomers of clopenthixol in patients given cis(Z)-clopenthixol or cis(Z)/trans(E)-clopenthixol. Acta Psychiatr Scand Suppl. 1981;294:70-7. PubMed PMID: 6951396. 2: Aaes-Jørgensen T. Serum concentrations of cis(Z)- and trans(E)-clopenthixol after administration of cis(Z)-clopenthixol and clopenthixol to human volunteers. Acta Psychiatr Scand Suppl. 1981;294:64-9. PubMed PMID: 6951395.