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MedKoo Cat#: 565248 | Name: RU1968 bis-TFA

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RU1968 bis-TFA salt is an inhibitor of the sperm-specific Ca2+ channel CatSper, thereby inhibiting human Slo3 with about 15-fold lower potency than CatSper.

Chemical Structure

RU1968 bis-TFA
RU1968 bis-TFA
CAS#171336-24-6 (free base)

Theoretical Analysis

MedKoo Cat#: 565248

Name: RU1968 bis-TFA

CAS#: 171336-24-6 (free base)

Chemical Formula: C28H40F6N2O5

Exact Mass: 0.0000

Molecular Weight: 598.63

Elemental Analysis: C, 56.18; H, 6.74; F, 19.04; N, 4.68; O, 13.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
171336-24-6 (free base) 6173-89-3 (HCl)
Synonym
RU1968 bis-TFA salt; RU-1968 bis-TFA salt; RU 1968 bis-TFA salt
IUPAC/Chemical Name
(8S,9S,13S,14S,17S)-17-(1-((2-(dimethylamino)ethyl)amino)ethyl)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-ol bis(2,2,2-trifluoroacetate)
InChi Key
SWTWSFQTQAEGEQ-BIADSQNLSA-N
InChi Code
InChI=1S/C24H38N2O.2C2HF3O2/c1-16(25-13-14-26(3)4)22-9-10-23-21-7-5-17-15-18(27)6-8-19(17)20(21)11-12-24(22,23)2;2*3-2(4,5)1(6)7/h6,8,15-16,20-23,25,27H,5,7,9-14H2,1-4H3;2*(H,6,7)/t16?,20-,21-,22-,23+,24-;;/m1../s1
SMILES Code
OC1=CC=C2[C@@]3([H])CC[C@]4(C)[C@@H](C(NCCN(C)C)C)CC[C@@]4([H])[C@]3([H])CCC2=C1.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 598.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Rennhack A, Schiffer C, Brenker C, Fridman D, Nitao ET, Cheng YM, Tamburrino L, Balbach M, Stölting G, Berger TK, Kierzek M, Alvarez L, Wachten D, Zeng XH, Baldi E, Publicover SJ, Benjamin Kaupp U, Strünker T. A novel cross-species inhibitor to study the function of CatSper Ca(2+) channels in sperm. Br J Pharmacol. 2018 Aug;175(15):3144-3161. doi: 10.1111/bph.14355. Epub 2018 Jun 29. PubMed PMID: 29723408; PubMed Central PMCID: PMC6031884.

View History

KC-11

KC-11