SB-587094 | CAS#949142-44-3 | MetAP-2 inhibitor

MedKoo Cat#: 407997 | Name: SB-587094

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SB-587094 is Reversible Methionine Aminopeptidase‑2 (MetAP-2) Inhibitor

Chemical Structure

SB-587094

CAS#949142-44-3

Theoretical Analysis

MedKoo Cat#: 407997

Name: SB-587094

CAS#: 949142-44-3

Chemical Formula: C16H18N4S2

Exact Mass: 330.0973

Molecular Weight: 330.47

Elemental Analysis: C, 58.15; H, 5.49; N, 16.95; S, 19.40

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

SB-587094; SB 587094; SB587094;

IUPAC/Chemical Name

N-(2-isopropylphenyl)-5-((thiophen-2-ylmethyl)thio)-4H-1,2,4-triazol-3-amine

InChi Key

QMNSHLAPQLBIGP-UHFFFAOYSA-N

InChi Code

InChI=1S/C16H18N4S2/c1-11(2)13-7-3-4-8-14(13)17-15-18-16(20-19-15)22-10-12-6-5-9-21-12/h3-9,11H,10H2,1-2H3,(H2,17,18,19,20)

SMILES Code

CC(C)C1=C(NC2=NN=C(SCC3=CC=CS3)N2)C=CC=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Co- and post-translational processing are crucial maturation steps to generate functional proteins. MetAP-2 plays an important role in this process, and inhibition of its proteolytic activity has been shown to be important for angiogenesis and tumor growth, suggesting that small-molecule inhibitors of MetAP-2 may be promising options for the treatment of cancer.

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 330.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Discovery and Structure-Based Optimization of Next-Generation Reversible Methionine Aminopeptidase-2 (MetAP-2) Inhibitors Timo Heinrich, Jeyaprakashnarayanan Seenisamy, Beatrix Blume, Jörg Bomke, Michel Calderini, Uwe Eckert, Manja Friese-Hamim, Rainer Kohl, Martin Lehmann, Birgitta Leuthner, Djordje Musil, Felix Rohdich, and Frank T. Zenke Publication Date (Web): April 2, 2019 (Article) DOI: 10.1021/acs.jmedchem.9b00041