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MedKoo Cat#: 584904 | Name: Solanoside

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Solanoside is a polyphenolic monomer compound extracted from Nerium oleander and has been found to have antitumor effects on various tumors at low doses.

Chemical Structure

Solanoside
Solanoside
CAS#4356-33-6

Theoretical Analysis

MedKoo Cat#: 584904

Name: Solanoside

CAS#: 4356-33-6

Chemical Formula: C30H46O8

Exact Mass: 534.3193

Molecular Weight: 534.69

Elemental Analysis: C, 67.39; H, 8.67; O, 23.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Solanoside; Odoroside
IUPAC/Chemical Name
Card-20(22)-enolide, 3-((6-deoxy-3-O-methyl-alpha-L-mannopyranosyl)oxy)- 14-hydroxy-, (3-beta,5-beta)-
InChi Key
VPUNMTHWNSJUOG-OHIZAEECSA-N
InChi Code
InChI=1S/C30H46O8/c1-16-24(32)26(35-4)25(33)27(37-16)38-19-7-10-28(2)18(14-19)5-6-22-21(28)8-11-29(3)20(9-12-30(22,29)34)17-13-23(31)36-15-17/h13,16,18-22,24-27,32-34H,5-12,14-15H2,1-4H3/t16-,18+,19-,20+,21-,22+,24-,25+,26+,27-,28-,29+,30-/m0/s1
SMILES Code
O=C1OCC([C@H]2CC[C@]3(O)[C@]4([H])CC[C@]5([H])C[C@@H](O[C@H]6[C@@H]([C@@H]([C@H]([C@H](C)O6)O)OC)O)CC[C@]5(C)[C@@]4([H])CC[C@]23C)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 534.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ko YS, Rugira T, Jin H, Park SW, Kim HJ. Oleandrin and Its Derivative Odoroside A, Both Cardiac Glycosides, Exhibit Anticancer Effects by Inhibiting Invasion via Suppressing the STAT-3 Signaling Pathway. Int J Mol Sci. 2018 Oct 26;19(11). pii: E3350. doi: 10.3390/ijms19113350. Review. PubMed PMID: 30373171; PubMed Central PMCID: PMC6274837. 2: Takada Y, Matsuo K, Ogura H, Bai L, Toki A, Wang L, Ando M, Kataoka T. Odoroside A and ouabain inhibit Na+/K+-ATPase and prevent NF-kappaB-inducible protein expression by blocking Na+-dependent amino acid transport. Biochem Pharmacol. 2009 Nov 1;78(9):1157-66. doi: 10.1016/j.bcp.2009.06.027. Epub 2009 Jun 25. PubMed PMID: 19559678. 3: Satoh D, Horie M. Studies on digitalis glycosides. XXV. Preparation of 14-beta, 15-beta-epoxycardenolides from odoroside H and digitoxin. Chem Pharm Bull (Tokyo). 1966 Oct;14(10):1133-7. PubMed PMID: 5976940. 4: ISHII H, OKUMURA T, OYAMA Y, SATOH D, WADA T. Studies on Digitalis glycosides. VI. Isolation of odoroside H, digiproside, and digitalonin. Pharm Bull. 1956 Aug;4(4):284-91. PubMed PMID: 13378953. 5: Ali SR, Haque S, Mudassar -, Versiani MA, Faizi S, Farooq AD. Cytotoxicity and chromosomal aberrations induced by methanolic extract of Cuscuta reflexa and its pure compounds on meristematic cells of Allium species. Pak J Pharm Sci. 2017 Mar;30(2):521-529. PubMed PMID: 28649079. 6: Wen S, Chen Y, Lu Y, Wang Y, Ding L, Jiang M. Cardenolides from the Apocynaceae family and their anticancer activity. Fitoterapia. 2016 Jul;112:74-84. doi: 10.1016/j.fitote.2016.04.023. Epub 2016 May 7. Review. PubMed PMID: 27167183. 7: Rashan LJ, Franke K, Khine MM, Kelter G, Fiebig HH, Neumann J, Wessjohann LA. Characterization of the anticancer properties of monoglycosidic cardenolides isolated from Nerium oleander and Streptocaulon tomentosum. J Ethnopharmacol. 2011 Apr 12;134(3):781-8. doi: 10.1016/j.jep.2011.01.038. Epub 2011 Feb 1. PubMed PMID: 21291990. 8: Okina Y, Takeuchi F, Yokomichi T, Takada Y, Kataoka T. Cardenolide aglycones inhibit tumor necrosis factor α-induced expression of intercellular adhesion molecule-1 at the translation step by blocking Na⁺/K⁺-ATPase. Biol Pharm Bull. 2015;38(1):39-47. doi: 10.1248/bpb.b14-00532. PubMed PMID: 25744456. 9: Siddiqui BS, Khatoon N, Begum S, Farooq AD, Qamar K, Bhatti HA, Ali SK. Flavonoid and cardenolide glycosides and a pentacyclic triterpene from the leaves of Nerium oleander and evaluation of cytotoxicity. Phytochemistry. 2012 May;77:238-44. doi: 10.1016/j.phytochem.2012.01.001. Epub 2012 Jan 24. PubMed PMID: 22281382. 10: Stuhlemmer U, Kreis W, Eisenbeiss M, Reinhard E. Cardiac glycosides in partly submerged shoots of Digitalis lanata. Planta Med. 1993 Dec;59(6):539-45. PubMed PMID: 8302954. 11: Wang X, Plomley JB, Newman RA, Cisneros A. LC/MS/MS analyses of an oleander extract for cancer treatment. Anal Chem. 2000 Aug 1;72(15):3547-52. PubMed PMID: 10952541. 12: Begum S, Siddiqui BS, Sultana R, Zia A, Suria A. Bio-active cardenolides from the leaves of Nerium oleander. Phytochemistry. 1999 Feb;50(3):435-8. PubMed PMID: 9933955.

View History

Solanacol

Solanacol