MedKoo Cat#: 584901 | Name: Nicanartine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Nicanartine is an antioxidant with potential plaque-reducing effect for atherosclerosis.

Chemical Structure

Nicanartine
Nicanartine
CAS#150443-71-3

Theoretical Analysis

MedKoo Cat#: 584901

Name: Nicanartine

CAS#: 150443-71-3

Chemical Formula: C23H33NO2

Exact Mass: 355.2511

Molecular Weight: 355.52

Elemental Analysis: C, 77.70; H, 9.36; N, 3.94; O, 9.00

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Nicanartine
IUPAC/Chemical Name
2,6-Di-tert-butyl-4-(3-(3-pyridylmethoxy)propyl)phenol
InChi Key
YNBBIPPQHYZTQF-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H33NO2/c1-22(2,3)19-13-17(14-20(21(19)25)23(4,5)6)10-8-12-26-16-18-9-7-11-24-15-18/h7,9,11,13-15,25H,8,10,12,16H2,1-6H3
SMILES Code
OC1=C(C(C)(C)C)C=C(CCCOCC2=CC=CN=C2)C=C1C(C)(C)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 355.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lupp A, Kerst S, Karge E, Quack G, Klinger W. Investigation on possible antioxidative properties of the NMDA-receptor antagonists ketamine, memantine, and amantadine in comparison to nicanartine in vitro. Exp Toxicol Pathol. 1998 Sep;50(4-6):501-6. PubMed PMID: 9784030. 2: Dailly E, Urien S, Wülfroth P, Tillement JP. Nicanartine improves in vitro resistance of lipoproteins to oxidation. Pharm Res. 1996 Mar;13(3):457-61. PubMed PMID: 8692742. 3: Hammes HP, Bartmann A, Engel L, Wülfroth P. Antioxidant treatment of experimental diabetic retinopathy in rats with nicanartine. Diabetologia. 1997 Jun;40(6):629-34. PubMed PMID: 9222640. 4: Wohlfrom M, Hanke S, Kamenz J, Voisard R, Heise N, Seibold W, Lenz C, Quack G, Wühlfroth P, Hanke H. Effect of the antioxidant Nicanartine on the proliferative and inflammatory response after experimental balloon angioplasty. Coron Artery Dis. 1998;9(12):831-7. PubMed PMID: 9894928. 5: Heinle H, Wülfroth P, Quack G, Lang F. Effects of the new antioxidant nicanartine in an experimental model of atherosclerosis. Arzneimittelforschung. 1996 Oct;46(10):956-9. PubMed PMID: 8931887. 6: Dailly E, Urien S, Tillement JP. Chain-breaking antioxidants and ferriheme-bound drugs are synergistic inhibitors of erythrocyte membrane peroxidation. Free Radic Res. 1998 Feb;28(2):205-14. PubMed PMID: 9645396. 7: Dailly E. [Study of lipid peroxidation inhibition in human blood by several endogenous and exogenous compounds]. Ann Pharm Fr. 2000 Oct;58(5):303-7. French. PubMed PMID: 11060406.