SPB07479 is a Chk1 inhibitor with potential as an anti-cancer agent (IC50 = 4.24 µM). SPB07479 promotes the formation of multinucleated cells, which allows for the cell cycle checkpoint to be overridden. In glioma and pancreatic cancer cell lines, SPB07479 was found to have antiproliferative effects, as well as chemosensitized the cancer cells, while leaving normal cells unaffected.
MedKoo Cat#: 130111
Name: SPB07479
CAS#: N/A
Chemical Formula: C21H18N4O5S
Exact Mass: 438.0998
Molecular Weight: 438.46
Elemental Analysis: Chemical Formula: Exact Mass: Molecular Weight: Elemental Analysis: C, 57.53; H, 4.14; N, 12.78; O, 18.24; S, 7.31
The following data is based on the product molecular weight 438.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
