MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 584898 | Name: Triperiden

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Triperiden, also known as Norakin, is an anticholinergic anti-Parkinson drug.

Chemical Structure

Triperiden
Triperiden
CAS#14617-17-5

Theoretical Analysis

MedKoo Cat#: 584898

Name: Triperiden

CAS#: 14617-17-5

Chemical Formula: C21H30ClNO

Exact Mass: 347.2016

Molecular Weight: 347.93

Elemental Analysis: C, 72.50; H, 8.69; Cl, 10.19; N, 4.03; O, 4.60

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Triperiden; Norakin
IUPAC/Chemical Name
1-Piperidinepropanol, alpha-phenyl-alpha-tricyclo(2.2.1.02,6)hept-3-yl-, hydrochloride (VAN)
InChi Key
HWSIZQMXQQXDNZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H29NO.ClH/c23-21(16-7-3-1-4-8-16,9-12-22-10-5-2-6-11-22)20-15-13-17-18(14-15)19(17)20;/h1,3-4,7-8,15,17-20,23H,2,5-6,9-14H2;1H
SMILES Code
OC(C1C2C3C2CC1C3)(C4=CC=CC=C4)CCN5CCCCC5.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 347.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Veckenstedt A, Güttner J, Schroeder C. Inhibition by Norakin (triperiden) of Sindbis virus infection in mice. Acta Virol. 1985 May;29(3):209-15. PubMed PMID: 2864821. 2: Ott S, Wunderli-Allenspach H. Effect of the virostatic Norakin (triperiden) on influenza virus activities. Antiviral Res. 1994 May;24(1):37-42. Review. PubMed PMID: 7944312. 3: Borchert HH, Pipping H, Pfeifer S. [Metabolic interactions of propiverin and triperiden]. Pharmazie. 1986 Jan;41(1):66-7. German. PubMed PMID: 3960957. 4: Haussner M, Pfeifer S, Franke P, Voigt G. [Triperiden (Norakin): biotransformation in vivo and in vitro]. Pharmazie. 1988 Jul;43(7):489-92. German. PubMed PMID: 3222281. 5: Presber HW, Schroeder C, Hegenscheid B, Heider H, Reefschläger J, Rosenthal HA. Antiviral activity of Norakin (triperiden) and related anticholinergic antiparkinsonism drugs. Acta Virol. 1984 Nov;28(6):501-7. PubMed PMID: 6152129. 6: Oka M, Ishiwata Y, Iwata N, Honda N, Kakigami T. Synthesis and anti-influenza virus activity of tricyclic compounds with a unique amine moiety. Chem Pharm Bull (Tokyo). 2001 Apr;49(4):379-83. PubMed PMID: 11310661. 7: Ghendon Y, Markushin S, Heider H, Melnikov S, Lotte V. Haemagglutinin of influenza A virus is a target for the antiviral effect of Norakin. J Gen Virol. 1986 Jun;67 ( Pt 6):1115-22. PubMed PMID: 3711865. 8: Heider H, Markushin S, Schroeder C, Ghendon Y. The influence of Norakin on the reproduction of influenza A and B viruses. Arch Virol. 1985;86(3-4):283-90. PubMed PMID: 2415085. 9: Markushin SG, Ginzburg VP, Khaĭder AM, Iarosh VV, Ivas'ko EA, Klimov AI. [Factors that cause a change in the antigenic structure of of the influenza virus hemagglutinin]. Vopr Virusol. 1992 Jul-Aug;37(4):196-9. Russian. PubMed PMID: 1281944. 10: Pfeifer S, Haussner M, Gründemann E, Lücke L. [Triperidin (Norakin): separation, stability and structure of stereoisomers]. Pharmazie. 1988 Feb;43(2):102-5. German. PubMed PMID: 3393574. 11: Prösch S, Heider H, Schroeder C, Shilov AA, Sinitzyn BV, Blinov VM, Krüger DH, Frömmel C. Mapping mutations in influenza A virus resistant to norakin. FEBS Lett. 1990 Jul 2;267(1):19-21. PubMed PMID: 2365087. 12: Klimov AI, Markushin SG, Prösch S, Ginzburg VP, Heider H, Heider AM, Schröeder C, Webster RG. Relation between drug resistance and antigenicity among norakin-resistant mutants of influenza A (fowl plague) virus. Arch Virol. 1992;124(1-2):147-55. PubMed PMID: 1373939. 13: Mentel R, Schroeder C, Döhner L. Effects of norakin on respiratory syncytial virus in tissue culture and in mice. Acta Virol. 1989 Mar;33(2):162-6. PubMed PMID: 2569812. 14: Prösch S, Heider H, Schroeder C, Krüger DH. Mutations in the hemagglutinin gene associated with influenza virus resistance to norakin. Arch Virol. 1988;102(1-2):125-9. PubMed PMID: 3196166. 15: Schroeder C, Heider H, Hegenscheid B, Schöffel M, Bubovich VI, Rosenthal HA. The anticholinergic anti-Parkinson drug Norakin selectively inhibits influenza virus replication. Antiviral Res. 1985;Suppl 1:95-9. PubMed PMID: 2417553.

View History

PD 163449

PD 163449