Furagin | CAS#1672-88-4 | antibacterial

MedKoo Cat#: 573519 | Name: Furagin

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Furazidine, also known as Akritoin, Furazidine, is anti-infective agent used for urinary tract infections. It is active against both gram-positive (Staphylococcus epidermidis, Staphylococcus aureus, Staphylococcus faecalis) and gram-negative microorganisms (Enterobacteriaceae – Salmonella, Shygella, Proteus, Klebsiella, Escherichia, Enterobacter, etc.). It is used for the treatment of urinary tract, skin and soft tissues infections.

Chemical Structure

Furagin

CAS#1672-88-4 (free base)

Theoretical Analysis

MedKoo Cat#: 573519

Name: Furagin

CAS#: 1672-88-4 (free base)

Chemical Formula: C10H8N4O5

Exact Mass: 264.0495

Molecular Weight: 264.20

Elemental Analysis: C, 45.46; H, 3.05; N, 21.21; O, 30.28

Price and Availability

Size	Price	Availability
250mg	USD 250.00	2 Weeks
1g	USD 450.00	2 Weeks
5g	USD 850.00	2 Weeks

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Related CAS #

1672-88-4 (free base) 22060-47-5 (sodium) 21287-44-5 (potassium)

Synonym

Furagin; Furazidin; Akritoin, Furazidine; NF 416; NF-416; NF416;

IUPAC/Chemical Name

2,4-Imidazolidinedione, 1-((3-(5-nitro-2-furanyl)-2-propen-1-ylidene)amino)-

InChi Key

DECBQELQORZLLP-UAIOPKHMSA-N

InChi Code

InChI=1S/C10H8N4O5/c15-8-6-13(10(16)12-8)11-5-1-2-7-3-4-9(19-7)14(17)18/h1-5H,6H2,(H,12,15,16)/b2-1+,11-5+

SMILES Code

O=C1NC(CN1/N=C/C=C/C2=CC=C([N+]([O-])=O)O2)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 264.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

This message contains search results from the National Center for Biotechnology Information (NCBI) at the U.S. National Library of Medicine (NLM). Do not reply directly to this message Sent On: Wed May 06 11:01:45 2020 20 selected items PubMed Results Items 1-20 of 20 (Display the 20 citations in PubMed) 1: Pustenko A, Nocentini A, Gratteri P, Bonardi A, Vozny I, Žalubovskis R, Supuran CT. The antibiotic furagin and its derivatives are isoform-selective human carbonic anhydrase inhibitors. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1011-1020. doi: 10.1080/14756366.2020.1752201. PMID: 32297543; PMCID: PMC7178874. 2: Dybowski B, Jabłońska O, Radziszewski P, Gromadzka-Ostrowska J, Borkowski A. Ciprofloxacin and furagin in acute cystitis: comparison of early immune and microbiological results. Int J Antimicrob Agents. 2008 Feb;31(2):130-4. doi: 10.1016/j.ijantimicag.2007.08.021. Epub 2007 Dec 3. PMID: 18060746. 3: Slapsyte G, Jankauskiene A, Mierauskiene J, Lazutka JR. Cytogenetic analysis of children under long-term antibacterial therapy with nitroheterocyclic compound furagin. Mutat Res. 2001 Apr 5;491(1-2):25-30. doi: 10.1016/s1383-5718(01)00131-0. PMID: 11287294. 4: Zielonka TM, Demkow U, Kuś J. Płucna reakcja po furazydynie (Furagin). Opis przypadku [Pulmonary reaction after furazidin (Furagin). Case report]. Pol Arch Med Wewn. 1997 May;97(5):465-72. Polish. PMID: 9411425. 5: Makareeva EN, Lozovskaia EL, Tatikolov AS, Sapezhinskiĭ II. Fotosensibiliziruiushchie svoĭstva i antioksidantnaia aktivnost' furagina-- antimikrobnogo lekarstvennogo preparata, proizvodnogo nitrofurana [Photosensitizing properties and antioxidant activity of furagin--an antimicrobial drug that is a derivative of nitrofuran]. Biofizika. 1997 Mar- Apr;42(2):472-9. Russian. PMID: 9172693. 6: Kuchuma ZN. Deĭstvie furagina, nistatina i levorina s zhelchnymi kislotami na vaginal'nuiu mikrofloru beremennykh [Action of furagin, nystatin and levorin with bile acids on the vaginal microflora of pregnant women]. Vrach Delo. 1986 Oct;(10):10-3. Russian. PMID: 3798871. 7: Sytnik IA, Tkachuk NI. Sovmestnoe deĭstvie benzilpenitsillina, furagina i zhelchnykh kislot na stafilokokki [Combined effect of benzylpenicillin, furagin and bile acids on staphylococci]. Antibiotiki. 1982 Nov;27(11):823-7. Russian. PMID: 7181465. 8: Paberza MIa, Gilev AP, Parinov VIa. Nekotorye aspekty ékskretsii furagina s mochoi u krolikov [Aspects of urinary furagin excretion in rabbits]. Farmatsiia. 1980 May-Jun;29(3):66-7. Russian. PMID: 7409226. 9: Suprun PP. Ekspresnyĭ atsydymetrychnyĭ metod vyznachennia rozchynnoho furahinu [Express acidimetric method of determining soluble furagin]. Farm Zh. 1980;(1):71-2. Ukrainian. PMID: 7371820. 10: Männistö P, Karttunen P. Pharmacokinetics of furagin, a new nitrofurantoin congener, on human volunteers. Int J Clin Pharmacol Biopharm. 1979 Jun;17(6):264-70. PMID: 468451. 11: Mis M, Boian M, Lente I, Shari B, Boda Z. Opyt primeneniia preparata furagina v lechenii infektsiĭ mochevykh putei [Use of furagin in treatment of urinary tract infections]. Ter Arkh. 1978;50(2):119-23. Russian. PMID: 25493. 12: Berliand AS, Knizhnik AZ, Fedorov EA, Utlinskaia MG, Kuperman AV. Kolichestvennoe opredelenie furagina v biologicheskikh zhidkostiakh [Quantitative determination of furagin in biological fluids]. Farmakol Toksikol. 1977 May-Jun;40(3):349-50. Russian. PMID: 902728. 13: Murav'ev IA, Melberg IaV, Shidlovska VA. Novaia lekarstvennaia forma furagina i metod ee analiza [New drug form of furagin and a method for its analysis]. Farmatsiia. 1976;25(2):15-7. Russian. PMID: 1269781. 14: Arons RM, Chursina TV. Primenenie sinteticheskikh pitatel'nykh sred s furantinom dlia vydeleniia sinegnoĭnykh bakterii [Use of synthetic nutrient media with furagin for the isolation of Pseudomonas aeruginosa]. Lab Delo. 1976;(3):179-80. Russian. PMID: 58130. 15: Arons RM. K voprosu o vliianii furagina, furazolina i furazolidona na fagotsitoz v opytakh in vitro [Effect of furagin, furazoline and furazolidone on phagocytosis in in vitro experiments]. Zh Mikrobiol Epidemiol Immunobiol. 1975 May;(5):133-4. Russian. PMID: 813458. 16: Arons RM, Chursina TV. Primenenie sredy s furaginom dlia vydeleniia sinegnoĭnykh bakteriĭ [Use of a furagin medium for isolating Pseudomonas pyocyanea]. Lab Delo. 1975;(9):554-5. Russian. PMID: 52751. 17: Murav'ev IA, Melberg IaV, Egert VE, Shidlovska VA. Spektrofotometricheskoe opredelenie soliubilizirovannogo furagina [Spectrophotometric determination of solubilized furagin]. Farmatsiia. 1974 Sep-Oct;23(5):22-4. Russian. PMID: 4464136. 18: Ruban AI. Antymikrobna diia kombinatsiĭ monomitsynu i furahinu z preparatom P-1 [Antimicrobial action of combinations of monomycin and furagin with preparation P-1]. Mikrobiol Zh. 1974 Jul-Aug;36(4):520-1. Ukrainian. PMID: 4619175. 19: Andreeva AT, Azhgikhin IS, Vetra IaA. Issledovanie nekotorykh veterinarnykh lekarstvennykh form, soderzhashchikh proizvodnye 5-nitrofurana (furagin, furazolidon, furatsilin [Study of some veterinary drug forms containing 5-nitrofuran derivatives (furagin, furazolidone, furacillin)]. Farmatsiia. 1973 Jan-Feb;22(1):20-6. Russian. PMID: 4704578. 20: Kurinna NV. Spektrofotometrychne vyznachenia likars'kych rechovyn pokhidnykh 5-nitrofuranu. II. Kil'liske vyznachennia furadoninu ta furaginu [Spectrophotometric determination of pharmacological agents of 5-nitrofurane derivatives. II. Quantitative determination of furadonin and furagin]. Farm Zh. 1971 Nov-Dec;26(6):15-9. Ukrainian. PMID: 5150534.