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MedKoo Cat#: 573510 | Name: AHR-5333 mandelate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AHR-5333 mandelate is an anti-allergy compound which has been shown to protect against antigen-induced anaphylactic collapse and ascaris antigen-induced skin hypersensitivity. AHR-5333 mandelate has also been shown to inhibit 5-HETE, LTB4 and LTC4 synthesis.

Chemical Structure

AHR-5333 mandelate
AHR-5333 mandelate
CAS#128766-12-1

Theoretical Analysis

MedKoo Cat#: 573510

Name: AHR-5333 mandelate

CAS#: 128766-12-1

Chemical Formula: C38H41F2NO7

Exact Mass: 661.2851

Molecular Weight: 661.74

Elemental Analysis: C, 68.97; H, 6.25; F, 5.74; N, 2.12; O, 16.92

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
AHR-5333 mandelate
IUPAC/Chemical Name
Benzeneacetic acid, alpha-hydroxy-, compd. with 1-(4-(3-(4-(bis(4-fluorophenyl)hydroxymethyl)-1-piperidinyl)propoxy)-3-methoxyphenyl)ethanone (1:1)
InChi Key
CFGSQJHZJYGYQO-UHFFFAOYSA-N
InChi Code
1S/C30H33F2NO4.C8H8O3/c1-21(34)22-4-13-28(29(20-22)36-2)37-19-3-16-33-17-14-25(15-18-33)30(35,23-5-9-26(31)10-6-23)24-7-11-27(32)12-8-24;9-7(8(10)11)6-4-2-1-3-5-6/h4-13,20,25,35H,3,14-19H2,1-2H3;1-5,7,9H,(H,10,11)
SMILES Code
COc1cc(ccc1OCCCN2CCC(CC2)C(O)(c3ccc(F)cc3)c4ccc(F)cc4)C(=O)C.OC(C(=O)O)c5ccccc5
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 661.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Graff G, Anderson LA. 1-[4-[3-[4-[bis(4-fluorophenyl)hydroxymethyl]-1- piperidinyl]propoxy]-3-methoxyphenyl]ethanone(AHR-5333): a selective human blood neutrophil 5-lipoxygenase inhibitor. Prostaglandins. 1989 Oct;38(4):473-96. PubMed PMID: 2554366. 2: Yanni JM, Halliwell RE, Tracy CH. Effect of AHR-5333 on flea antigen extract-induced skin reactions in flea-allergic dogs. J Vet Pharmacol Ther. 1988 Jun;11(2):221-5. PubMed PMID: 3184263. 3: Yanni JM, Foxwell MH. Effects of AHR-5333, a new potential antiallergy compound, in in vivo models of immediate hypersensitivity. Int Arch Allergy Appl Immunol. 1988;85(4):428-33. PubMed PMID: 2895747.