Clothiapine | CAS#2058-52-8 | atypical antipsychotic

MedKoo Cat#: 341514 | Name: Clothiapine

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Clothiapine, also known as Entumine, is an atypical antipsychotic of the dibenzothiazepine chemical class. It was first introduced in a few European countries (namely, Belgium, Italy, Spain and Switzerland), Argentina, Taiwan and Israel in 1970.

Chemical Structure

Clothiapine

CAS#2058-52-8

Theoretical Analysis

MedKoo Cat#: 341514

Name: Clothiapine

CAS#: 2058-52-8

Chemical Formula: C18H18ClN3S

Exact Mass: 343.0910

Molecular Weight: 343.87

Elemental Analysis: C, 62.87; H, 5.28; Cl, 10.31; N, 12.22; S, 9.32

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 350.00	2 Weeks
10mg	USD 650.00	2 Weeks

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Related CAS #

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Synonym

Clothiapine; Clotiapine; HF 2159; HF-2159; HF2159; LW 2159; LW2159; LW-2159; S-805C; S805C; S 805C; W 130; W130; W-130; Entumine; Clothiapin; Deliton; Etomine

IUPAC/Chemical Name

Dibenzo(b,f)(1,4)thiazepine, 2-chloro-11-(4-methyl-1-piperazinyl)-

InChi Key

KAAZGXDPUNNEFN-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H18ClN3S/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3

SMILES Code

CN1CCN(C2=NC3=CC=CC=C3SC4=CC=C(Cl)C=C24)CC1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 343.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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Analytical Challenge in Postmortem Toxicology Applied to a Human Body Found into a Lake after Three Years Immersion. J Forensic Sci. 2015 Sep;60(5):1383-6. doi: 10.1111/1556-4029.12815. Epub 2015 Aug 10. PubMed PMID: 26258895. 6: Wu CS, Tsai YT, Tsai HJ. Antipsychotic drugs and the risk of ventricular arrhythmia and/or sudden cardiac death: a nation-wide case-crossover study. J Am Heart Assoc. 2015 Feb 23;4(2). pii: e001568. doi: 10.1161/JAHA.114.001568. PubMed PMID: 25713294; PubMed Central PMCID: PMC4345877. 7: Wang EH, Yang AC. Pisa syndrome after discontinuation of clotiapine in a patient with intractable insomnia. J Clin Psychopharmacol. 2014 Apr;34(2):276-7. doi: 10.1097/JCP.0000000000000045. PubMed PMID: 24525650. 8: Declercq T, Petrovic M, Azermai M, Vander Stichele R, De Sutter AI, van Driel ML, Christiaens T. Withdrawal versus continuation of chronic antipsychotic drugs for behavioural and psychological symptoms in older people with dementia. Cochrane Database Syst Rev. 2013 Mar 28;(3):CD007726. doi: 10.1002/14651858.CD007726.pub2. Review. PubMed PMID: 23543555. 9: Devresse A, Maldague P, Coulier B, Pierard F, Gielen I. Focal parietal necrosis of the sigmoid due to atypical neuroleptics: a case report. Acta Gastroenterol Belg. 2012 Jun;75(2):263-5. PubMed PMID: 22870793. 10: Jayakody K, Gibson RC, Kumar A, Gunadasa S. Zuclopenthixol acetate for acute schizophrenia and similar serious mental illnesses. Cochrane Database Syst Rev. 2012 Apr 18;(4):CD000525. doi: 10.1002/14651858.CD000525.pub3. Review. PubMed PMID: 22513898; PubMed Central PMCID: PMC4175533. 11: Duran-Ferreras E, Duran-Ferreras A. [The usefulness of SPECT with 123I-ioflupane (DaTSCAN) in Parkinsonism induced by pharmaceuticals]. Rev Neurol. 2011 Mar 16;52(6):382-3. Spanish. PubMed PMID: 21387256. 12: Dilly S, Liégeois JF. Interaction of clozapine and its nitrenium ion with rat D2 dopamine receptors: in vitro binding and computational study. J Comput Aided Mol Des. 2011 Feb;25(2):163-9. doi: 10.1007/s10822-010-9407-8. Epub 2010 Dec 24. PubMed PMID: 21184252. 13: Aghayev E, Jackowski C, Christe A, Thali M. Radiopaque stomach contents in postmortem CT in suicidal oral medication intoxication: report of three cases. J Forensic Leg Med. 2010 Apr;17(3):164-8. doi: 10.1016/j.jflm.2009.10.001. Epub 2009 Nov 28. PubMed PMID: 20211459. 14: Sporkert F, Augsburger M, Giroud C, Brossard C, Eap CB, Mangin P. Determination and distribution of clotiapine (Entumine) in human plasma, post-mortem blood and tissue samples from clotiapine-treated patients and from autopsy cases. Forensic Sci Int. 2007 Aug 6;170(2-3):193-9. Epub 2007 Jul 5. PubMed PMID: 17614226. 15: Sánchez de la Torre C, Martínez MA, Almarza E. Determination of several psychiatric drugs in whole blood using capillary gas-liquid chromatography with nitrogen phosphorus detection: comparison of two solid phase extraction procedures. 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