MRT00200769 is an inhibitor of the inwardly rectifying potassium channel Kir7.1. MRT00200769 showed IC50 of 1.3 µM at Kir7.1. Kir7.1 is an inwardly rectifying potassium channel that has been implicated in controlling the resting membrane potential of the myometrium. Abnormal uterine activity in pregnancy plays an important role in postpartum hemorrhage, and novel therapies for this condition may lie in manipulation of membrane potential.
MedKoo Cat#: 565108
Name: MRT00200769
CAS#: 1214573-32-6
Chemical Formula: C21H26FNO4
Exact Mass: 375.1846
Molecular Weight: 375.44
Elemental Analysis: C, 67.18; H, 6.98; F, 5.06; N, 3.73; O, 17.05
The following data is based on the product molecular weight 375.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
