GSK866 | CAS# 960248-81-1 | SEGRA

MedKoo Cat#: 565095 | Name: GSK866

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSK866 is a selective glucocorticoid receptor agonist (SEGRA).

Chemical Structure

GSK866

CAS#960248-81-1

Theoretical Analysis

MedKoo Cat#: 565095

Name: GSK866

CAS#: 960248-81-1

Chemical Formula: C23H21Cl2F4N5O3

Exact Mass: 561.0958

Molecular Weight: 562.35

Elemental Analysis: C, 49.13; H, 3.76; Cl, 12.61; F, 13.51; N, 12.45; O, 8.54

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

GSK-866; GSK 866; GSK866

IUPAC/Chemical Name

5-Amino-N-[(2S)-2-({[(2,6-dichlorophenyl)carbonyl](ethyl)amino}methyl)- 3,3,3-trifluoro-2-hydroxypropyl]-1-(4-fluorophenyl)- 1H-pyrazole-4-carboxamide

InChi Key

LKQMULLPLYLIGW-QFIPXVFZSA-N

InChi Code

InChI=1S/C23H21Cl2F4N5O3/c1-2-33(21(36)18-16(24)4-3-5-17(18)25)12-22(37,23(27,28)29)11-31-20(35)15-10-32-34(19(15)30)14-8-6-13(26)7-9-14/h3-10,37H,2,11-12,30H2,1H3,(H,31,35)/t22-/m0/s1

SMILES Code

O=C(C1=C(N)N(C2=CC=C(F)C=C2)N=C1)NC[C@](O)(CN(C(C3=C(Cl)C=CC=C3Cl)=O)CC)C(F)(F)F

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 562.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Chirumamilla CS, Palagani A, Kamaraj B, Declerck K, Verbeek MWC, Oksana R, De Bosscher K, Bougarne N, Ruttens B, Gevaert K, Houtman R, De Vos WH, Joossens J, Van Der Veken P, Augustyns K, Van Ostade X, Bogaerts A, De Winter H, Vanden Berghe W. Selective Glucocorticoid Receptor Properties of GSK866 Analogs with Cysteine Reactive Warheads. Front Immunol. 2017 Nov 1;8:1324. doi: 10.3389/fimmu.2017.01324. eCollection 2017. PubMed PMID: 29163463; PubMed Central PMCID: PMC5672024. 2: Ryabtsova O, Joossens J, Van Der Veken P, Vanden Berghe W, Augustyns K, De Winter H. Novel selective glucocorticoid receptor agonists (SEGRAs) with a covalent warhead for long-lasting inhibition. Bioorg Med Chem Lett. 2016 Oct 15;26(20):5032-5038. doi: 10.1016/j.bmcl.2016.08.091. Epub 2016 Aug 31. PubMed PMID: 27612544.