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MedKoo Cat#: 584868 | Name: KI-7
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

KI-7 is an adenosine A2B receptor positive allosteric modulator.

Chemical Structure

KI-7
KI-7
CAS#1489263-00-4

Theoretical Analysis

MedKoo Cat#: 584868

Name: KI-7

CAS#: 1489263-00-4

Chemical Formula: C23H18N2O2

Exact Mass: 354.1368

Molecular Weight: 354.41

Elemental Analysis: C, 77.95; H, 5.12; N, 7.90; O, 9.03

Price and Availability

Size Price Availability Quantity
10mg USD 385.00 2 Weeks
25mg USD 785.00 2 Weeks
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Related CAS #
No Data
Synonym
KI-7; KI7; KI 7
IUPAC/Chemical Name
alpha-Oxo-N-phenyl-1-(phenylmethyl)-1H-indole-3-acetamide
InChi Key
MQMGZFRIEZRHHJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H18N2O2/c26-22(23(27)24-18-11-5-2-6-12-18)20-16-25(15-17-9-3-1-4-10-17)21-14-8-7-13-19(20)21/h1-14,16H,15H2,(H,24,27)
SMILES Code
O=C(NC1=CC=CC=C1)C(C2=CN(CC3=CC=CC=C3)C4=C2C=CC=C4)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
KI-7 is an A2B adenosine receptor positive allosteric modulator.
In vitro activity:
In the early phase of differentiation programme, KI-7 significantly potentiated physiological and A2B AR agonist-mediated down-regulation of IL-6 release. Conversely, during the late stage of differentiation, when most of the cells have an osteoblast phenotype, KI-7 caused a sustained raise in IL-6 levels and an improvement in osteoblast viability. Reference: Biochim Biophys Acta. 2014 Dec;1843(12):2957-66. https://pubmed.ncbi.nlm.nih.gov/25241343/
In vivo activity:
TBD
Solvent mg/mL mM
Solubility
DMSO 133.9 377.70
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 354.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Trincavelli ML, Daniele S, Giacomelli C, Taliani S, Da Settimo F, Cosimelli B, Greco G, Novellino E, Martini C. Osteoblast differentiation and survival: A role for A2B adenosine receptor allosteric modulators. Biochim Biophys Acta. 2014 Dec;1843(12):2957-66. doi: 10.1016/j.bbamcr.2014.09.013. Epub 2014 Sep 18. PMID: 25241343.
In vitro protocol:
1. Trincavelli ML, Daniele S, Giacomelli C, Taliani S, Da Settimo F, Cosimelli B, Greco G, Novellino E, Martini C. Osteoblast differentiation and survival: A role for A2B adenosine receptor allosteric modulators. Biochim Biophys Acta. 2014 Dec;1843(12):2957-66. doi: 10.1016/j.bbamcr.2014.09.013. Epub 2014 Sep 18. PMID: 25241343.
In vivo protocol:
TBD
Trincavelli et al (2014) Osteoblast differentiation and survival: A role for A2B adenosine receptor allosteric modulators. Biochim.Biophys.Acta 1843 2957 PMID: 25241343 Trincavelli et al (2014) Allosteric modulators of human A2B adenosine receptor. Biochim.Biophys.Acta 1840 1194 PMID: 24361612

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