Synonym
KIN-8741; KIN8741; KIN 8741
IUPAC/Chemical Name
(S)-N-(3,5-difluoro-4-((6-((1-hydroxypropan-2-yl)oxy)-7-methoxyquinolin-4-yl)oxy)phenyl)-4-methoxynicotinamide
InChi Key
GCIKJNJUNJFZPR-AWEZNQCLSA-N
InChi Code
InChI=1S/C26H23F2N3O6/c1-14(13-32)36-24-10-16-20(11-23(24)35-3)30-7-5-22(16)37-25-18(27)8-15(9-19(25)28)31-26(33)17-12-29-6-4-21(17)34-2/h4-12,14,32H,13H2,1-3H3,(H,31,33)/t14-/m0/s1
SMILES Code
OC[C@H](C)OC1=C(OC)C=C(N=CC=C2OC3=C(F)C=C(NC(C4=C(OC)C=CN=C4)=O)C=C3F)C2=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
511.48
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Ouyang XS, Grandinetti KB, Boren M, Chakravorty S, Chopade S, Jiang P, Kanouni T, Koudriakova T, Makwana O, Pack SK, Perez M, Suriben R, Timple N, Thohan S, Uryu S, Womble S, Yuan D, Kania RS, Cox JM. Discovery of KIN-8741, a Highly Selective Type IIb c-Met Kinase Inhibitor with Broad Mutation Coverage and Quality Drug-Like Properties for the Treatment of Cancer. J Med Chem. 2025 Jun 3. doi: 10.1021/acs.jmedchem.5c00834. Epub ahead of print. PMID: 40459881.
