GSK-1264 | CAS# 1392118-63-6 | HIV Integrase Inhibitor

MedKoo Cat#: 565058 | Name: GSK-1264

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSK-1264 is an allosteric inhibitor of human immunodeficiency virus (HIV) integrase which blocks viral replication and abnormal multimerization involving specific protein domains.

Chemical Structure

GSK-1264

CAS#1392118-63-6

Theoretical Analysis

MedKoo Cat#: 565058

Name: GSK-1264

CAS#: 1392118-63-6

Chemical Formula: C26H28FNO5

Exact Mass: 453.1952

Molecular Weight: 453.51

Elemental Analysis: C, 68.86; H, 6.22; F, 4.19; N, 3.09; O, 17.64

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

GSK1264; GSK-1264; GSK 1264

IUPAC/Chemical Name

(S)-2-(tert-butoxy)-2-(4-(8-fluoro-5-methylchroman-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl)acetic acid

InChi Key

LDALHHGVIZRJPA-QHCPKHFHSA-N

InChi Code

InChI=1S/C26H28FNO5/c1-14-15-11-8-12-32-22(15)19(27)13-18(14)20-16-9-6-7-10-17(16)24(29)28(5)21(20)23(25(30)31)33-26(2,3)4/h6-7,9-10,13,23H,8,11-12H2,1-5H3,(H,30,31)/t23-/m0/s1

SMILES Code

CC1=C(C(C2=C3C=CC=C2)=C([C@H](OC(C)(C)C)C(O)=O)N(C)C3=O)C=C(F)C4=C1CCCO4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 453.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Gupta K, Turkki V, Sherrill-Mix S, Hwang Y, Eilers G, Taylor L, McDanal C, Wang P, Temelkoff D, Nolte RT, Velthuisen E, Jeffrey J, Van Duyne GD, Bushman FD. Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase. PLoS Biol. 2016 Dec 9;14(12):e1002584. doi: 10.1371/journal.pbio.1002584. eCollection 2016 Dec. PubMed PMID: 27935939; PubMed Central PMCID: PMC5147827. 2: Gupta K, Brady T, Dyer BM, Malani N, Hwang Y, Male F, Nolte RT, Wang L, Velthuisen E, Jeffrey J, Van Duyne GD, Bushman FD. Allosteric inhibition of human immunodeficiency virus integrase: late block during viral replication and abnormal multimerization involving specific protein domains. J Biol Chem. 2014 Jul 25;289(30):20477-88. PubMed PMID: 24904063; PubMed Central PMCID: PMC4110260.