AZ2 | CAS#N/A | selective inhibitor

MedKoo Cat#: 565690 | Name: AZ2

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AZ2 is a first-in-class highly selective inhibitor of pi3kγ, binding to an active state and exhibiting over 1000 fold of selectivity over pi3kα and pi3kβ

Chemical Structure

AZ2

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 565690

Name: AZ2

CAS#: N/A

Chemical Formula: C20H23N3O2S

Exact Mass: 369.1511

Molecular Weight: 369.48

Elemental Analysis: C, 65.02; H, 6.27; N, 11.37; O, 8.66; S, 8.68

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

AZ2; AZ 2; AZ-2

IUPAC/Chemical Name

(S)-N-(5-(2-(1-Cyclopropylethyl)-7-methyl-1-oxoisoindolin-5-yl)-4-methylthiazol-2-yl)acetamide

InChi Key

CNCRCDLWUGCPSJ-LBPRGKRZSA-N

InChi Code

InChI=1S/C20H23N3O2S/c1-10-7-15(18-11(2)21-20(26-18)22-13(4)24)8-16-9-23(19(25)17(10)16)12(3)14-5-6-14/h7-8,12,14H,5-6,9H2,1-4H3,(H,21,22,24)/t12-/m0/s1

SMILES Code

CC(NC1=NC(C)=C(C2=CC3=C(C(N([C@H](C4CC4)C)C3)=O)C(C)=C2)S1)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 369.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Li Y, Gong P, Hou JX, Huang W, Ma XP, Wang YL, Li J, Cui XB, Li N. miR-34a Regulates Multidrug Resistance via Positively Modulating OAZ2 Signaling in Colon Cancer Cells. J Immunol Res. 2018 Aug 2;2018:7498514. doi: 10.1155/2018/7498514. eCollection 2018. PubMed PMID: 30175154; PubMed Central PMCID: PMC6098920. 2: Liu K, Yu J, Zhao J, Zhou Y, Xiong N, Xu J, Wang T, Bell RL, Qing H, Lin Z. (AZI2)3'UTR Is a New SLC6A3 Downregulator Associated with an Epistatic Protection Against Substance Use Disorders. Mol Neurobiol. 2018 Jul;55(7):5611-5622. doi: 10.1007/s12035-017-0781-2. Epub 2017 Oct 5. PubMed PMID: 28983843; PubMed Central PMCID: PMC5886844. 3: Fukasaka M, Ori D, Kawagoe T, Uematsu S, Maruyama K, Okazaki T, Kozaki T, Imamura T, Tartey S, Mino T, Satoh T, Akira S, Takeuchi O. Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation. J Immunol. 2013 Jun 1;190(11):5702-11. doi: 10.4049/jimmunol.1203155. Epub 2013 Apr 22. PubMed PMID: 23610142. 4: Gross JA, Fiori LM, Labonté B, Lopez JP, Turecki G. Effects of promoter methylation on increased expression of polyamine biosynthetic genes in suicide. J Psychiatr Res. 2013 Apr;47(4):513-9. doi: 10.1016/j.jpsychires.2012.11.016. Epub 2012 Dec 20. PubMed PMID: 23260169; PubMed Central PMCID: PMC5293536. 5: Fiori LM, Gross JA, Turecki G. Effects of histone modifications on increased expression of polyamine biosynthetic genes in suicide. Int J Neuropsychopharmacol. 2012 Sep;15(8):1161-6. doi: 10.1017/S1461145711001520. Epub 2011 Oct 19. PubMed PMID: 22008221. 6: Murakami Y, Suzuki J, Samejima K, Oka T. Developmental alterations in expression and subcellular localization of antizyme and antizyme inhibitor and their functional importance in the murine mammary gland. Amino Acids. 2010 Feb;38(2):591-601. doi: 10.1007/s00726-009-0422-9. Epub 2009 Dec 8. PubMed PMID: 19997757. 7: Geerts D, Koster J, Albert D, Koomoa DL, Feith DJ, Pegg AE, Volckmann R, Caron H, Versteeg R, Bachmann AS. The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification. Int J Cancer. 2010 May 1;126(9):2012-24. doi: 10.1002/ijc.25074. PubMed PMID: 19960435; PubMed Central PMCID: PMC2847573. 8: Funami K, Sasai M, Ohba Y, Oshiumi H, Seya T, Matsumoto M. Spatiotemporal mobilization of Toll/IL-1 receptor domain-containing adaptor molecule-1 in response to dsRNA. J Immunol. 2007 Nov 15;179(10):6867-72. PubMed PMID: 17982077. 9: Sasai M, Shingai M, Funami K, Yoneyama M, Fujita T, Matsumoto M, Seya T. NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction. J Immunol. 2006 Dec 15;177(12):8676-83. PubMed PMID: 17142768. 10: Fujita F, Taniguchi Y, Kato T, Narita Y, Furuya A, Ogawa T, Sakurai H, Joh T, Itoh M, Delhase M, Karin M, Nakanishi M. Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling. Mol Cell Biol. 2003 Nov;23(21):7780-93. PubMed PMID: 14560022; PubMed Central PMCID: PMC207563. 11: Ivanov IP, Gesteland RF, Atkins JF. A second mammalian antizyme: conservation of programmed ribosomal frameshifting. Genomics. 1998 Sep 1;52(2):119-29. PubMed PMID: 9782076.