Chlorantraniliprole | CAS# 500008-45-7 | Ryanodine Receptor Activator

MedKoo Cat#: 565032 | Name: Chlorantraniliprole

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Chlorantraniliprole is a potent and selective ryanodine receptor activator.

Chemical Structure

Chlorantraniliprole

CAS#500008-45-7

Theoretical Analysis

MedKoo Cat#: 565032

Name: Chlorantraniliprole

CAS#: 500008-45-7

Chemical Formula: C18H14BrCl2N5O2

Exact Mass: 480.9708

Molecular Weight: 483.15

Elemental Analysis: C, 44.75; H, 2.92; Br, 16.54; Cl, 14.67; N, 14.50; O, 6.62

Price and Availability

Size	Price	Availability
200mg	USD 750.00	2 Weeks
500mg	USD 1,650.00	2 Weeks
1g	USD 2,950.00	2 Weeks
2g	USD 5,250.00	2 Weeks

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Related CAS #

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Synonym

DPX-E2Y45; DPX E2Y45; DPXE2Y45; Chlorantraniliprole

IUPAC/Chemical Name

5-Bromo-N-[4-chloro-2-methyl-6-(methylcarbamoyl)phenyl]-2-(3-chloropyridin-2-yl)pyrazole-3-carboxamide

InChi Key

PSOVNZZNOMJUBI-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H14BrCl2N5O2/c1-9-6-10(20)7-11(17(27)22-2)15(9)24-18(28)13-8-14(19)25-26(13)16-12(21)4-3-5-23-16/h3-8H,1-2H3,(H,22,27)(H,24,28)

SMILES Code

O=C(C1=CC(Br)=NN1C2=NC=CC=C2Cl)NC3=C(C(NC)=O)C=C(Cl)C=C3C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 483.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: He F, Sun S, Tan H, Sun X, Shang D, Yao C, Qin C, Ji S, Li X, Zhang J, Jiang X. Compatibility of chlorantraniliprole with the generalist predator Coccinella septempunctata L. (Coleoptera: Coccinellidae) based toxicity, life-cycle development and population parameters in laboratory microcosms. Chemosphere. 2019 Mar 6;225:182-190. doi: 10.1016/j.chemosphere.2019.03.025. [Epub ahead of print] PubMed PMID: 30875501. 2: Hafeez M, Liu S, Jan S, Gulzar A, Fernández-Grandon GM, Qasim M, Khan KA, Ali B, Kedir SJ, Fahad M, Wang M. Enhanced effects of dietary tannic acid with chlorantraniliprole on life table parameters and nutritional physiology of Spodoptera exigua (Hübner). Pestic Biochem Physiol. 2019 Mar;155:108-118. doi: 10.1016/j.pestbp.2019.01.012. Epub 2019 Jan 29. PubMed PMID: 30857620. 3: Zhao J, Xu L, Sun Y, Song P, Han Z. UDP-Glycosyltransferase Genes in the Striped Rice Stem Borer, Chilo suppressalis (Walker), and Their Contribution to Chlorantraniliprole Resistance. Int J Mol Sci. 2019 Mar 1;20(5). pii: E1064. doi: 10.3390/ijms20051064. PubMed PMID: 30823656. 4: Magyar ZÉ, Diszházi G, Péli-Szabó J, Szentesi P, Collet C, Csernoch L, Nánás P, Almássy J. The diamide insecticide chlorantraniliprole increases the single-channel current activity of the mammalian skeletal muscle ryanodine receptor. Gen Physiol Biophys. 2019 Mar 1. doi: 10.4149/gpb_2019007. [Epub ahead of print] PubMed PMID: 30821253. 5: Kadala A, Charreton M, Charnet P, Collet C. Honey bees long-lasting locomotor deficits after exposure to the diamide chlorantraniliprole are accompanied by brain and muscular calcium channels alterations. Sci Rep. 2019 Feb 15;9(1):2153. doi: 10.1038/s41598-019-39193-3. PubMed PMID: 30770849; PubMed Central PMCID: PMC6377601. 6: Bolzan A, Padovez FEO, Nascimento ARB, Kaiser IS, Lira EC, Amaral FSA, Kanno RH, Malaquias JB, Omoto C. Selection and characterization of the inheritance of resistance of Spodoptera frugiperda (Lepidoptera: Noctuidae) to chlorantraniliprole and cross-resistance to other diamide insecticides. Pest Manag Sci. 2019 Feb 14. doi: 10.1002/ps.5376. [Epub ahead of print] PubMed PMID: 30761724. 7: Wei Y, Yan R, Zhou Q, Qiao L, Zhu G, Chen M. Monitoring and Mechanisms of Chlorantraniliprole Resistance in Chilo suppressalis (Lepidoptera: Crambidae) in China. J Econ Entomol. 2019 Feb 1. doi: 10.1093/jee/toz001. [Epub ahead of print] PubMed PMID: 30715398. 8: Plata-Rueda A, Martínez LC, Costa NCR, Zanuncio JC, de Sena Fernandes ME, Serrão JE, Guedes RNC, Fernandes FL. Chlorantraniliprole-mediated effects on survival, walking abilities, and respiration in the coffee berry borer, Hypothenemus hampei. Ecotoxicol Environ Saf. 2019 May 15;172:53-58. doi: 10.1016/j.ecoenv.2019.01.063. Epub 2019 Jan 22. PubMed PMID: 30682633. 9: Bird LJ, Walker PW. Baseline Susceptibility of Helicoverpa punctigera (Lepidoptera: Noctuidae) to Indoxacarb, Emamectin Benzoate, and Chlorantraniliprole. J Econ Entomol. 2019 Mar 21;112(2):818-826. doi: 10.1093/jee/toy389. PubMed PMID: 30566638. 10: Oliveira RL, Gontijo PC, Sâmia RR, Carvalho GA. Long-term effects of chlorantraniliprole reduced risk insecticide applied as seed treatment on lady beetle Harmonia axyridis (Coleoptera: Coccinellidae). Chemosphere. 2019 Mar;219:678-683. doi: 10.1016/j.chemosphere.2018.12.058. Epub 2018 Dec 10. PubMed PMID: 30557724. 11: Chen J, Xue L, Wei R, Liu S, Yin CC. The insecticide chlorantraniliprole is a weak activator of mammalian skeletal ryanodine receptor/Ca(2+) release channel. Biochem Biophys Res Commun. 2019 Jan 8;508(2):633-639. doi: 10.1016/j.bbrc.2018.11.180. Epub 2018 Dec 4. PubMed PMID: 30527809. 12: Li X, Shan C, Li F, Liang P, Smagghe G, Gao X. Transcription factor FTZ-F1 and cis-acting elements mediate expression of CYP6BG1 conferring resistance to chlorantraniliprole in Plutella xylostella. Pest Manag Sci. 2019 Apr;75(4):1172-1180. doi: 10.1002/ps.5279. Epub 2019 Jan 7. PubMed PMID: 30471186. 13: Nakajima T, Otsuka K, Tomizawa S, Masubuchi T, Kamijo K, Yamaki Y, Yoshikawa S, Hasegawa E, Kokaji Y, Watanabe S, Hashimoto T. Surveillance of Chlorantraniliprole Residues in Vegetables and Fruits Using LC-MS/MS. Shokuhin Eiseigaku Zasshi. 2018;59(5):234-238. doi: 10.3358/shokueishi.59.234. PubMed PMID: 30429423. 14: Chen Y, Yan Y, Ren ZF, Ganeteg U, Yao GK, Li ZL, Huang T, Li JH, Tian YQ, Lin F, Xu HH. AtLHT1 Transporter Can Facilitate the Uptake and Translocation of a Glycinergic-Chlorantraniliprole Conjugate in Arabidopsis thaliana. J Agric Food Chem. 2018 Nov 28;66(47):12527-12535. doi: 10.1021/acs.jafc.8b03591. Epub 2018 Nov 16. PubMed PMID: 30403859. 15: Kim AY, Kwon DH, Jeong IH, Koh YH. An investigation of the molecular and biochemical basis underlying chlorantraniliprole-resistant Drosophila strains and their cross-resistance to other insecticides. Arch Insect Biochem Physiol. 2018 Dec;99(4):e21514. doi: 10.1002/arch.21514. Epub 2018 Nov 5. PubMed PMID: 30397935. 16: Carscallen GE, Kher SV, Evenden ML. Efficacy of Chlorantraniliprole Seed Treatments Against Armyworm (Mythimna unipuncta [Lepidoptera: Noctuidae]) Larvae on Corn (Zea mays). J Econ Entomol. 2019 Feb 12;112(1):188-195. doi: 10.1093/jee/toy338. PubMed PMID: 30388266. 17: Noh HH, Lee JY, Park HK, Lee JW, Jo SH, Kim JH, Kwon H, Kyung KS. Risk of dermal and inhalation exposure to chlorantraniliprole assessed by using whole-body dosimetry in Korea. Pest Manag Sci. 2019 Apr;75(4):1159-1165. doi: 10.1002/ps.5255. Epub 2019 Jan 17. PubMed PMID: 30375145. 18: Truong KM, Pessah IN. Comparison of Chlorantraniliprole and Flubendiamide Activity Toward Wild-Type and Malignant Hyperthermia-Susceptible Ryanodine Receptors and Heat Stress Intolerance. Toxicol Sci. 2019 Feb 1;167(2):509-523. doi: 10.1093/toxsci/kfy256. PubMed PMID: 30329129; PubMed Central PMCID: PMC6358238. 19: Xu L, Zhao J, Sun Y, Xu D, Xu G, Xu X, Zhang Y, Huang S, Han Z, Gu Z. Constitutive overexpression of cytochrome P450 monooxygenase genes contributes to chlorantraniliprole resistance in Chilo suppressalis (Walker). Pest Manag Sci. 2019 Mar;75(3):718-725. doi: 10.1002/ps.5171. Epub 2018 Sep 28. PubMed PMID: 30101471. 20: Wang JD, Wang WZ, Wang YR, Gao SJ, Elzaki M, Wang R, Wang R, Wu M. Response of detoxification and immune genes and of transcriptome expression in Mythimna separata following chlorantraniliprole exposure. Comp Biochem Physiol Part D Genomics Proteomics. 2018 Dec;28:90-98. doi: 10.1016/j.cbd.2018.07.001. Epub 2018 Jul 7. PubMed PMID: 30005390.