MedKoo Cat#: 573427 | Name: Adaprolol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Adaprolol is a beta-adrenergic antagonist. Enantiomers of Adaprolol may be used in the treatment of Glaucoma or other ailments of the eye.

Chemical Structure

Adaprolol
Adaprolol
CAS#101479-70-3 (free base)

Theoretical Analysis

MedKoo Cat#: 573427

Name: Adaprolol

CAS#: 101479-70-3 (free base)

Chemical Formula: C26H39NO4

Exact Mass: 429.2879

Molecular Weight: 429.60

Elemental Analysis: C, 72.69; H, 9.15; N, 3.26; O, 14.90

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
Synonym
Adaprolol; CDDD 2803; CDDD-2803; CDDD2803; HGP 2; HGP-2;
IUPAC/Chemical Name
2-((3r,5r,7r)-adamantan-1-yl)ethyl 2-(4-(2-hydroxy-3-(isopropylamino)propoxy)phenyl)acetate
InChi Key
IPGLIOFIFLXLKR-AXYNENQYSA-N
InChi Code
InChI=1S/C26H39NO4/c1-18(2)27-16-23(28)17-31-24-5-3-19(4-6-24)12-25(29)30-8-7-26-13-20-9-21(14-26)11-22(10-20)15-26/h3-6,18,20-23,27-28H,7-17H2,1-2H3/t20-,21+,22-,23?,26?
SMILES Code
O=C(CC1=CC=C(OCC(O)CNC(C)C)C=C1)OCCC2(C3)C[C@@H](C[C@@H]3C4)C[C@@H]4C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 429.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bodor N, Buchwald P. Ophthalmic drug design based on the metabolic activity of the eye: soft drugs and chemical delivery systems. AAPS J. 2005 Dec 7;7(4):E820-33. Review. PubMed PMID: 16594634; PubMed Central PMCID: PMC2750951. 2: Boder N, Elkoussi A, Zuobi K, Kovacs P. Synthesis and pharmacological activity of adaprolol enantiomers: a new soft drug for treating glaucoma. J Ocul Pharmacol Ther. 1996 Summer;12(2):115-22. PubMed PMID: 8773927. 3: Polgar P, Bodor N. Cardiac electrophysiologic effects of adaprolol maleate, a new beta-blocker, in closed chest dogs. Life Sci. 1991;48(16):1519-28. PubMed PMID: 1673212.