Synonym
2-Hydroxysebacic acid; Decandioic acid; 2-hydroxy-; CID128458; LMFA01170076.
IUPAC/Chemical Name
(R)-2-hydroxydecanedioic acid
InChi Key
LPIOYESQKJFWPQ-MRVPVSSYSA-N
InChi Code
InChI=1S/C10H18O5/c11-8(10(14)15)6-4-2-1-3-5-7-9(12)13/h8,11H,1-7H2,(H,12,13)(H,14,15)/t8-/m1/s1
SMILES Code
C([C@@H](CCCCCCCC(=O)O)O)(=O)O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
218.25
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Nakai A. [Floppy female infant with congenital hydrocephalus, hepatic dysfunction and refractory convulsions]. No To Hattatsu. 2011 Nov;43(6):433-4. Japanese. PubMed PMID: 22180956.
2: Basilio A, Justice M, Harris G, Bills G, Collado J, de la Cruz M, Diez MT, Hernandez P, Liberator P, Nielsen kahn J, Pelaez F, Platas G, Schmatz D, Shastry M, Tormo JR, Andersen GR, Vicente F. The discovery of moriniafungin, a novel sordarin derivative produced by Morinia pestalozzioides. Bioorg Med Chem. 2006 Jan 15;14(2):560-6. Epub 2005 Sep 23. PubMed PMID: 16183294.
3: Muth A, Mosandl A, Wanders RJ, Nowaczyk MJ, Baric I, Böhles H, Sewell AC. Stereoselective analysis of 2-hydroxysebacic acid in urine of patients with Zellweger syndrome and of premature infants fed with medium-chain triglycerides. J Inherit Metab Dis. 2003;26(6):583-92. PubMed PMID: 14605504.
4: Muth A, Jung J, Bilke S, Scharrer A, Mosandl A, Sewell AC, Böhles H. Simultaneous enantioselective analysis of chiral urinary metabolites in patients with Zellweger syndrome. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Jul 25;792(2):269-77. PubMed PMID: 12860034.
5: Shimizu N, Yamaguchi S, Orii T. A study of urinary metabolites in patients with dicarboxylic aciduria for differential diagnosis. Acta Paediatr Jpn. 1994 Apr;36(2):139-45. PubMed PMID: 8203256.
6: Kajita M, Iwase K, Matsumoto M, Kuhara T, Sinka T, Matsumoto I. [Clinical and biochemical studies in a case of acute encephalopathy associated with calcium hopanthenate administration]. No To Hattatsu. 1990 May;22(3):267-73. Review. Japanese. PubMed PMID: 2194543.
7: Rocchiccioli F, Cartier PH, Aubourg P, Bougnères PF. Mass spectrometric identification of 2-hydroxy-sebacic acid in the urines of patients with neonatal adrenoleukodystrophy and Zellweger syndrome. Biomed Environ Mass Spectrom. 1986 Jun;13(6):315-8. PubMed PMID: 2943344.
