Synonym
4-HBD; 4 HBD; 4HBD
IUPAC/Chemical Name
4-Hydroxy-3,4'-bichromenyl-2,2'-dione
InChi Key
JWXINGPRTCQRLO-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H10O5/c19-15-9-12(10-5-1-3-7-13(10)22-15)16-17(20)11-6-2-4-8-14(11)23-18(16)21/h1-9,20H
SMILES Code
O=C1C(C(C2=C(O3)C=CC=C2)=CC3=O)=C(O)C4=C(O1)C=CC=C4
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
306.27
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Lau MW, Dale BE. Effect of primary degradation-reaction products from Ammonia Fiber Expansion (AFEX)-treated corn stover on the growth and fermentation of Escherichia coli KO11. Bioresour Technol. 2010 Oct;101(20):7849-55. doi: 10.1016/j.biortech.2010.04.076. Epub 2010 Jun 2. PubMed PMID: 20627718.
2: Mukherjee A, Ghosh S, Sarkar R, Samanta S, Ghosh S, Pal M, Majee A, Sen SK, Singh B. Synthesis, characterization and unravelling the molecular interaction of new bioactive 4-hydroxycoumarin derivative with biopolymer: Insights from spectroscopic and theoretical aspect. J Photochem Photobiol B. 2018 Dec;189:124-137. doi: 10.1016/j.jphotobiol.2018.10.003. Epub 2018 Oct 13. PubMed PMID: 30342308.
3: Dondelinger Y, Declercq W, Montessuit S, Roelandt R, Goncalves A, Bruggeman I, Hulpiau P, Weber K, Sehon CA, Marquis RW, Bertin J, Gough PJ, Savvides S, Martinou JC, Bertrand MJ, Vandenabeele P. MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates. Cell Rep. 2014 May 22;7(4):971-81. doi: 10.1016/j.celrep.2014.04.026. Epub 2014 May 9. PubMed PMID: 24813885.
