WJ460 is a potent inhibitor of myoferlin (MYOF), a protein implicated in cancer cell invasion and metastasis. By directly binding to MYOF, WJ460 effectively suppresses breast cancer cell invasion, with IC₅₀ values of approximately 43.37 nM in MDA-MB-231 cells. In vivo studies demonstrate that WJ460 inhibits breast tumor growth, angiogenesis, and spontaneous metastasis in mouse models. Additionally, WJ460 has been shown to induce ferroptosis, a form of regulated cell death, in pancreatic cancer cells.
MedKoo Cat#: 564969
Name: WJ460
CAS#: 1415251-36-3
Chemical Formula: C27H28N2O3S
Exact Mass: 460.1821
Molecular Weight: 460.59
Elemental Analysis: C, 70.41; H, 6.13; N, 6.08; O, 10.42; S, 6.96
The following data is based on the product molecular weight 460.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
