WS-383 is a Highly Potent, Selective, and Cellular Active Triazolo[1,5-a]Pyrimidine-Based Inhibitors Targeting the DCN1-UBC12 Protein-Protein Interaction. WS-383 blocks the DCN1−UBC12 interaction (IC50 = 11 nM) reversibly and shows selectivity over selected kinases. WS-383 exhibits cellular target engagement to DCN1 in MGC-803 cells. WS-383 inhibits Cul3/1 neddylation selectively over other cullins and also induces accumulation of p21, p27, and NRF2. ( J Med Chem. 2019 Feb 25. doi: 10.1021)
MedKoo Cat#: 555446
Name: WS-383
CAS#: 2247544-02-9 (HCl)
Chemical Formula: C18H21Cl2N9S2
Exact Mass:
Molecular Weight: 498.45
Elemental Analysis: C, 43.37; H, 4.25; Cl, 14.22; N, 25.29; S, 12.86
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 49.8 | 100.00 |
The following data is based on the product molecular weight 498.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
