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MedKoo Cat#: 564945 | Name: DS42450411

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DS42450411 is a potent orally active hepcidin production inhibitor.

Chemical Structure

DS42450411
DS42450411
CAS#NONE

Theoretical Analysis

MedKoo Cat#: 564945

Name: DS42450411

CAS#: NONE

Chemical Formula: C22H28N4

Exact Mass: 348.2314

Molecular Weight: 348.49

Elemental Analysis: C, 75.82; H, 8.10; N, 16.08

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
DS 42450411; DS-42450411; DS42450411
IUPAC/Chemical Name
8-(1-(trans-4-Aminocyclohexyl)vinyl)-5,5-dimethyl-5,6-dihydrobenzo[h]quinazolin-4-amine
InChi Key
ADLAJVKSIHBUEZ-CZIWCDLHSA-N
InChi Code
InChI=1S/C22H28N4/c1-13(14-4-7-17(23)8-5-14)15-6-9-18-16(10-15)11-22(2,3)19-20(18)25-12-26-21(19)24/h6,9-10,12,14,17H,1,4-5,7-8,11,23H2,2-3H3,(H2,24,25,26)/t14-,17-
SMILES Code
NC1=C2C(C)(C)CC3=CC(C([C@H]4CC[C@H](N)CC4)=C)=CC=C3C2=NC=N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
The inhibition of hepcidin may be a favorable strategy for the treatment of anemia of chronic disease.

Preparing Stock Solutions

The following data is based on the product molecular weight 348.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Fukuda T, Ishiyama T, Katagiri T, Ueda K, Muramatsu S, Hashimoto M, Aki A, Baba D, Watanabe K, Tanaka N. Discovery of DS42450411 as a potent orally active hepcidin production inhibitor: Design and optimization of novel 4-aminopyrimidine derivatives. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3333-3337. doi: 10.1016/j.bmcl.2018.09.010. Epub 2018 Sep 8. PubMed PMID: 30217414.