Sadopine | CAS#111127-62-9 | radioligand

MedKoo Cat#: 461692 | Name: Sadopine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sadopine is an excellent high affinity, high specific activity radioligand to label selectively the DHP receptor of L-type Ca2+ channels in tissue sections as well as in membrane fragments.

Chemical Structure

Sadopine

CAS#111127-62-9

Theoretical Analysis

MedKoo Cat#: 461692

Name: Sadopine

CAS#: 111127-62-9

Chemical Formula: C30H40F3N3O7S

Exact Mass: 643.2539

Molecular Weight: 643.71

Elemental Analysis: C, 55.98; H, 6.26; F, 8.85; N, 6.53; O, 17.40; S, 4.98

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Sadopine;

IUPAC/Chemical Name

3-(2-(2-((tert-butoxycarbonyl)amino)-4-(methylthio)butanamido)ethyl) 5-ethyl 2,6-dimethyl-4-(2-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3,5-dicarboxylate

InChi Key

IAGRRCQYHMPXJH-UHFFFAOYSA-N

InChi Code

InChI=1S/C30H40F3N3O7S/c1-8-41-26(38)22-17(2)35-18(3)23(24(22)19-11-9-10-12-20(19)30(31,32)33)27(39)42-15-14-34-25(37)21(13-16-44-7)36-28(40)43-29(4,5)6/h9-12,21,24,35H,8,13-16H2,1-7H3,(H,34,37)(H,36,40)

SMILES Code

O=C(C1=C(C)NC(C)=C(C(OCC)=O)C1C2=CC=CC=C2C(F)(F)F)OCCNC(C(NC(OC(C)(C)C)=O)CCSC)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 643.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Knaus HG, Striessnig J, Hering S, Marrer S, Schwenner E, Höltje HD, Glossmann H. [35S]sadopine, a novel high affinity, high specific activity, L-type Ca2+ channel probe: characterization of two equipotent diastereomers with opposite allosteric properties. Mol Pharmacol. 1992 Feb;41(2):298-307. PubMed PMID: 1311409. 2: Glossmann H, Striessnig J, Knaus HG, Müller J, Grassegger A, Höltje HD, Marrer S, Hymel L, Schindler HG. Structure of calcium channels. Ann N Y Acad Sci. 1989;560:198-214. Review. PubMed PMID: 2545133.