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MedKoo Cat#: 573408 | Name: Azidopine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Azidopine is a photoactive dihydropyridine channel blocker which may also act as a multidrug resistant (MDR) modulator.

Chemical Structure

Azidopine
Azidopine
CAS#90523-31-2

Theoretical Analysis

MedKoo Cat#: 573408

Name: Azidopine

CAS#: 90523-31-2

Chemical Formula: C27H26F3N5O5

Exact Mass: 557.1886

Molecular Weight: 557.53

Elemental Analysis: C, 58.17; H, 4.70; F, 10.22; N, 12.56; O, 14.35

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Azidopine
IUPAC/Chemical Name
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-(trifluoromethyl)phenyl)-, 2-((4-azidobenzoyl)amino)ethyl ethyl ester
InChi Key
SWMHKFTXBOJETC-UHFFFAOYSA-N
InChi Code
1S/C27H26F3N5O5/c1-4-39-25(37)21-15(2)33-16(3)22(23(21)19-7-5-6-8-20(19)27(28,29)30)26(38)40-14-13-32-24(36)17-9-11-18(12-10-17)34-35-31/h5-12,23,33H,4,13-14H2,1-3H3,(H,32,36)
SMILES Code
CCOC(=O)C1=C(NC(=C(C1c2ccccc2C(F)(F)F)C(=O)OCCNC(=O)c3ccc(cc3)N=N#N)C)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 557.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Striessnig J, Murphy BJ, Catterall WA. Dihydropyridine receptor of L-type Ca2+ channels: identification of binding domains for [3H](+)-PN200-110 and [3H]azidopine within the alpha 1 subunit. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10769-73. PubMed PMID: 1660150; PubMed Central PMCID: PMC53012. 2: Tamai I, Safa AR. Azidopine noncompetitively interacts with vinblastine and cyclosporin A binding to P-glycoprotein in multidrug resistant cells. J Biol Chem. 1991 Sep 5;266(25):16796-800. PubMed PMID: 1679434. 3: Sehested M, Skovsgaard T, Jensen PB, Demant EJ, Friche E, Bindslev N. Transport of the multidrug resistance modulators verapamil and azidopine in wild type and daunorubicin resistant Ehrlich ascites tumour cells. Br J Cancer. 1990 Jul;62(1):37-41. PubMed PMID: 1975202; PubMed Central PMCID: PMC1971743. 4: Bruggemann EP, Germann UA, Gottesman MM, Pastan I. Two different regions of P-glycoprotein [corrected] are photoaffinity-labeled by azidopine. J Biol Chem. 1989 Sep 15;264(26):15483-8. Erratum in: J Biol Chem 1990 Mar 5;265(7):4172. PubMed PMID: 2475500.

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