Imanixil, also known as SAR-088 and HOE-402, is a PIP5K2B inhibitor. SAR088 showed reasonable potency, selectivity and physicochemical properties in enzymatic and cellular assays. In vivo, SAR088 lowered blood glucose levels of obese and hyperglycemic male Zucker diabetic fatty rats treated for 3 weeks. Thus, SAR088 represents the first orally available and in vivo active PIP5K2B inhibitor and provides an excellent starting point for the development of potent and selective PIP5K2B inhibitors for the treatment of insulin resistance and diabetes.
MedKoo Cat#: 564939
Name: Imanixil
CAS#: 75689-93-9
Chemical Formula: C17H17F3N6O2
Exact Mass: 394.1365
Molecular Weight: 394.36
Elemental Analysis: C, 51.78; H, 4.35; F, 14.45; N, 21.31; O, 8.11
The following data is based on the product molecular weight 394.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
-O-propionate0903.jpg "Camptothecin-20(S)-O-propionate")
