HS-10296 is a potent, selective and orally active EGFR tyrosine kinase inhibitor. HS-10296 binds to and inhibits EGFR T790M, a secondarily acquired resistance mutation, inhibits the tyrosine kinase activity of EGFR T790M, prevents EGFR T790M-mediated signaling and leads to cell death in EGFR T790M-expressing tumor cells. EGFR, a receptor tyrosine kinase that is mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization.
MedKoo Cat#: 207021
Name: HS-10296 mesylate
CAS#: 2134096-06-1 (mesylate)
Chemical Formula: C31H39N7O5S
Exact Mass: 0.0000
Molecular Weight: 621.76
Elemental Analysis: C, 59.89; H, 6.32; N, 15.77; O, 12.87; S, 5.16
The following data is based on the product molecular weight 621.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
