Iobenguane I 131 | CAS# 77679-27-7 | Guanidine Analog

MedKoo Cat#: 573398 | Name: Iobenguane I 131

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Iobenguane I 131 is a guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. The radiolabeled forms are used as antineoplastic agents and radioactive imaging agents. MIBG serves as a neuron-blocking agent which has a strong affinity for, and retention in, the adrenal medulla and also inhibits ADP-ribosyltransferase.

Chemical Structure

Iobenguane I 131

CAS#77679-27-7

Theoretical Analysis

MedKoo Cat#: 573398

Name: Iobenguane I 131

CAS#: 77679-27-7

Chemical Formula: C8H10131IN3

Exact Mass: 278.9936

Molecular Weight: 279.09

Elemental Analysis: C, 34.43; H, 3.61; I, 46.90; N, 15.06

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

3-Iodobenzylguanidine, 131I-MIBG, Azedra, I-131 MIBG, Iobenguane (131I) , Iobenguane I 131, MIBG, MIBG-(131 I), Ultratrace iobenguane I131

IUPAC/Chemical Name

(m-Iodo-(sup 131)I-benzyl)guanidine

InChi Key

PDWUPXJEEYOOTR-JRGAVVOBSA-N

InChi Code

1S/C8H10IN3/c9-7-3-1-2-6(4-7)5-12-8(10)11/h1-4H,5H2,(H4,10,11,12)/i9+4

SMILES Code

c1ccc(cc1[131I])CNC(N)=N

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 279.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kotecka-Blicharz A, Hasse-Lazar K, Handkiewicz-Junak D, Gawlik T, Pawlaczek A, Oczko-Wojciechowska M, Michalik B, Szpak-Ulczok S, Krajewska J, Jurecka-Lubieniecka B, Jarząb B. 131-I MIBG therapy of malignant pheochromocytoma and paraganglioma tumours - a single-centre study. Endokrynol Pol. 2018;69(3):246-251. doi: 10.5603/EP.a2018.0024. Epub 2018 Apr 12. PubMed PMID: 29645065. 2: Inaki A, Yoshimura K, Murayama T, Imai Y, Kuribayashi Y, Higuchi T, Jinguji M, Shiga T, Kinuya S. A phase I clinical trial for [(131)I]meta-iodobenzylguanidine therapy in patients with refractory pheochromocytoma and paraganglioma: a study protocol. J Med Invest. 2017;64(3.4):205-209. doi: 10.2152/jmi.64.205. PubMed PMID: 28954983. 3: Carrasquillo JA, Pandit-Taskar N, Chen CC. I-131 Metaiodobenzylguanidine Therapy of Pheochromocytoma and Paraganglioma. Semin Nucl Med. 2016 May;46(3):203-14. doi: 10.1053/j.semnuclmed.2016.01.011. Review. PubMed PMID: 27067501. 4: Vöö S, Bucerius J, Mottaghy FM. I-131-MIBG therapies. Methods. 2011 Nov;55(3):238-45. doi: 10.1016/j.ymeth.2011.10.006. Epub 2011 Oct 25. Review. PubMed PMID: 22056346.