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MedKoo Cat#: 330175 | Name: Tiamulin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tiamulin (previously thiamutilin) is a pleuromutilin antibiotic drug that is used in veterinary medicine particularly for pigs and poultry. Tiamulin is a diterpene antimicrobial with a pleuromutilin chemical structure similar to that of valnemulin.

Chemical Structure

Tiamulin
Tiamulin
CAS#55297-95-5 (free base)

Theoretical Analysis

MedKoo Cat#: 330175

Name: Tiamulin

CAS#: 55297-95-5 (free base)

Chemical Formula: C28H47NO4S

Exact Mass: 493.3226

Molecular Weight: 493.75

Elemental Analysis: C, 68.11; H, 9.60; N, 2.84; O, 12.96; S, 6.49

Price and Availability

Size Price Availability Quantity
100mg USD 450.00
200mg USD 750.00
500mg USD 1,550.00
1g USD 2,250.00
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Related CAS #
55297-95-5 (free base) 55297-96-6 9 (furmarate)
Synonym
SQ 14055; SQ-14055; SQ14055; Tiamulin;
IUPAC/Chemical Name
(3aS,4R,5S,6S,8R,9S,9aR,10R)-2-[[2-(Diethylamino)ethyl]thio]acetic Acid 6-Ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl Ester
InChi Key
UURAUHCOJAIIRQ-KWVPEQCVSA-N
InChi Code
InChI=1S/C28H47NO4S/c1-8-26(6)17-22(33-23(31)18-34-16-15-29(9-2)10-3)27(7)19(4)11-13-28(20(5)25(26)32)14-12-21(30)24(27)28/h8,19-20,22,24-25,32H,1,9-18H2,2-7H3/t19-,20+,22-,24+,25+,26-,27-,28+/m1/s1
SMILES Code
O=C(O[C@H]1[C@]([C@H](C)CC2)(C)[C@@](C(CC3)=O)([H])[C@]32[C@@H](C)[C@H](O)[C@](C)(C=C)C1)CSCCN(CC)CC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 493.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Liu K, Xia J, Li Y, Li BB, Wang MQ, Zhou Q, Ma ML, He QR, Yang WQ, Liu DF, Wang ZY, Yang LL, Zhang YY. Discovery of Novel Coumarin Pleuromutilin Derivatives as Potent Anti-MRSA Agents. J Med Chem. 2024 Dec 12;67(23):21030-21048. doi: 10.1021/acs.jmedchem.4c01678. Epub 2024 Nov 27. PMID: 39603597. 2: Yi Y, Zhang J, Lin S, Wang H, Li G, Yang S, Shang R, Zhang R, Li F. Design, synthesis, and biological evaluation of novel pleuromutilin derivatives with methicillin-resistant Staphylococcus aureus -targeting phenol linker groups. Eur J Med Chem. 2025 Jan 15;282:117061. doi: 10.1016/j.ejmech.2024.117061. Epub 2024 Nov 13. PMID: 39550822. 3: Xie N, Ma T, Gao Y, Fu J, Tan C, Wang Z, Wang Z, Krüger-Haker H, Feßler AT, Wu C, Shen J, Schwarz S, Wang Y. Two novel plasmids harbouring the multiresistance gene cfr in porcine Staphylococcus equorum. J Glob Antimicrob Resist. 2024 Oct 1;39:170-174. doi: 10.1016/j.jgar.2024.09.004. Epub ahead of print. PMID: 39362467. 4: Mahmood Q, Chantziaras I, Yasir A, Dewulf J. Establishing defined daily and course doses for antimicrobials used in Pakistani broilers to enable farm-level quantification and comparison of antimicrobial use. Prev Vet Med. 2024 Dec;233:106348. doi: 10.1016/j.prevetmed.2024.106348. Epub 2024 Sep 18. PMID: 39303427. 5: Wallgren P. Control of swine dysentery at national level in Sweden. Acta Vet Scand. 2024 Sep 5;66(1):44. doi: 10.1186/s13028-024-00769-3. PMID: 39238024; PMCID: PMC11378539. 6: Mitchaothai J, Grabowski NT, Lertpatarakomol R, Trairatapiwan T, Lukkananukool A. Bacterial Contamination and Antimicrobial Resistance in Two- Spotted (Gryllus bimaculatus) and House (Acheta domesticus) Cricket Rearing and Harvesting Processes. Vet Sci. 2024 Jul 1;11(7):295. doi: 10.3390/vetsci11070295. PMID: 39057979; PMCID: PMC11281677. 7: Zhang J, Chen S, Liu X, Yu X, Gu N, Li A. Discovery of 1,2,3-triazole-based pleuromutilin derivatives as potent gram-positive antibacterial agents. Bioorg Med Chem Lett. 2024 Sep 15;110:129878. doi: 10.1016/j.bmcl.2024.129878. Epub 2024 Jul 6. PMID: 38977107. 8: Massaccesi L, Albini E, Massacci FR, Giusepponi D, Paoletti F, Sdogati S, Morena F, Agnelli A, Leccese A, Magistrali CF, Galarini R. Impact of Soil Fertilization with Pig Slurry on Antibiotic Residues and Resistance Genes: A Longitudinal Study. Antibiotics (Basel). 2024 May 24;13(6):486. doi: 10.3390/antibiotics13060486. PMID: 38927154; PMCID: PMC11200711. 9: Xinle Z, Li Z, Jian L, Hui Z, Jinhua G, Hejia W. Characterization and In vivo Evaluation of Polymorphic Valnemulin Hydrogen Fumarate. Curr Drug Deliv. 2024 Jun 5. doi: 10.2174/0115672018289236240530095059. Epub ahead of print. PMID: 38847258. 10: Gerszon J, Büchse A, Genz B, Pollock Y, Gleeson B, Morris A, Sellars MJ, Moser RJ. The use of oral fluids and sock samples for monitoring key pathogens in pig populations for surveillance purposes. Prev Vet Med. 2024 Jul;228:106237. doi: 10.1016/j.prevetmed.2024.106237. Epub 2024 May 27. PMID: 38820832. 11: Liu HX, Yao WY, Cui G, Zhou J, Yan H, Guo H, Wang YW, Zhang Y. Design, synthesis, and antibacterial activity of pleuromutilin derivatives. Chem Biol Drug Des. 2024 Jun;103(6):e14554. doi: 10.1111/cbdd.14554. PMID: 38806405. 12: Xia Y, Wang Z, Hu Y, Zhao P, Li J, Zhang L, Fang R, Zhao J. Isolation, Identification, Genomic Diversity, and Antimicrobial Resistance Analysis of Streptococcus suis in Hubei Province of China from 2021 to 2023. Microorganisms. 2024 Apr 30;12(5):917. doi: 10.3390/microorganisms12050917. PMID: 38792744; PMCID: PMC11124115. 13: Lucca V, Borges KA, Furian TQ, Chitolina GZ, Streck AF, da Rocha DT, de Souza Moraes HL, Nascimento VP. Phenotypic and molecular characterisation of Salmonella spp. isolates in healthy poultry. Br Poult Sci. 2024 Aug;65(4):415-423. doi: 10.1080/00071668.2024.2337180. Epub 2024 May 8. PMID: 38717314. 14: Li K, Lin C, Hu YH, Wang J, Jin Z, Zeng ZL, Tang YZ. Design, Synthesis, Biological Evaluation, and Molecular Docking Studies of Pleuromutilin Derivatives Containing Thiazole. ACS Infect Dis. 2024 Jun 14;10(6):1980-1989. doi: 10.1021/acsinfecdis.3c00718. Epub 2024 May 4. PMID: 38703116. 15: Le Xuan A, Hsu FY, Hsueh PR, Lin WH, Chen HH, Chiou MT, Lin CN. Antimicrobial resistance profile in Salmonella enterica serovar Choleraesuis isolates from diseased pigs in Taiwan. J Microbiol Immunol Infect. 2024 Aug;57(4):660-664. doi: 10.1016/j.jmii.2024.04.005. Epub 2024 Apr 16. PMID: 38670815. 16: Sun P, Lootens O, Kabeta T, Reckelbus D, Furman N, Cao X, Zhang S, Antonissen G, Croubels S, De Boevre M, De Saeger S. Exploration of Cytochrome P450-Related Interactions between Aflatoxin B1 and Tiamulin in Broiler Chickens. Toxins (Basel). 2024 Mar 20;16(3):160. doi: 10.3390/toxins16030160. PMID: 38535826; PMCID: PMC10974768. 17: Uruén C, Gimeno J, Sanz M, Fraile L, Marín CM, Arenas J. Invasive Streptococcus suis isolated in Spain contain a highly promiscuous and dynamic resistome. Front Cell Infect Microbiol. 2024 Jan 22;13:1329632. doi: 10.3389/fcimb.2023.1329632. PMID: 38317790; PMCID: PMC10839070. 18: Stubberfield E, AbuOun M, Card RM, Welchman D, Anjum MF. Molecular characterization of antimicrobial resistance in Brachyspira species isolated from UK chickens: Identification of novel variants of pleuromutilin and beta- lactam resistance genes. Vet Microbiol. 2024 Mar;290:109992. doi: 10.1016/j.vetmic.2024.109992. Epub 2024 Jan 15. PMID: 38306769. 19: De Lorenzi G, Gherpelli Y, Luppi A, Pupillo G, Bassi P, Dottori M, Di Donato A, Merialdi G, Bonilauri P. In vitro susceptibility of Brachyspira hyodysenteriae strains isolated in pigs in northern Italy between 2005 and 2022. Res Vet Sci. 2024 Mar;168:105152. doi: 10.1016/j.rvsc.2024.105152. Epub 2024 Jan 11. PMID: 38219471. 20: Pavlović DM, Babić S, Čizmić M, Sertić M, Pinušić T. Simultaneous determination of macrolides in water samples by solid-phase extraction and capillary electrophoresis. Acta Pharm. 2023 Dec 26;73(4):515-535. doi: 10.2478/acph-2023-0041. PMID: 38147474.

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