MI-888 is a potent MDM2 inhibitor (Ki = 0.44 nM) with a superior pharmacokinetic profile and enhanced in vivo efficacy. MI-888 is capable of achieving rapid, complete, and durable tumor regression in two types of xenograft models of human cancer with oral administration and represents the most potent and efficacious MDM2 inhibitor reported to date.
MedKoo Cat#: 407975
Name: MI-888 free base
CAS#: 1303607-59-1 (free base)
Chemical Formula: C28H32Cl2FN3O3
Exact Mass: 547.1805
Molecular Weight: 548.48
Elemental Analysis: C, 61.32; H, 5.88; Cl, 12.93; F, 3.46; N, 7.66; O, 8.75
The following data is based on the product molecular weight 548.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
