MedKoo Cat#: 584806 | Name: NK 2367

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NK 2367 is a merocyanine-oxazolone dye that is membrane potential-sensitive.

Chemical Structure

NK 2367
CAS#71960-70-8

Theoretical Analysis

MedKoo Cat#: 584806

Name: NK 2367

CAS#: 71960-70-8

Chemical Formula: C21H22N2O5S2

Exact Mass: 446.0970

Molecular Weight: 446.54

Elemental Analysis: C, 56.49; H, 4.97; N, 6.27; O, 17.91; S, 14.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
NK 2367; NK-2367; NK2367
IUPAC/Chemical Name
1(4H)-Quinolinepropanesulfonic acid, 4-(4-(3-ethyl-4-oxo-2-thioxo-5-oxazolidinylidene)-2-butenylidene)-
InChi Key
JLLWEASFMYXWPS-ORLDQZBHSA-N
InChi Code
InChI=1S/C21H22N2O5S2/c1-2-23-20(24)19(28-21(23)29)11-6-3-8-16-12-14-22(13-7-15-30(25,26)27)18-10-5-4-9-17(16)18/h3-6,8-12,14H,2,7,13,15H2,1H3,(H,25,26,27)/b6-3+,16-8+,19-11-
SMILES Code
O=S(CCCN1C=C/C(C2=C1C=CC=C2)=C\C=C\C=C(OC(N3CC)=S)\C3=O)(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 446.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nakajima S, Gilai A. Radial propagation of muscle action potential along the tubular system examined by potential-sensitive dyes. J Gen Physiol. 1980 Dec;76(6):751-62. PubMed PMID: 10822502; PubMed Central PMCID: PMC2228607. 2: Delay M, Ribalet B, Vergara J. Caffeine potentiation of calcium release in frog skeletal muscle fibres. J Physiol. 1986 Jun;375:535-59. PubMed PMID: 3795067; PubMed Central PMCID: PMC1182774. 3: Senseman DM, Salzberg BM. Electrical activity in an exocrine gland: optical recording with a potentiometric dye. Science. 1980 Jun 13;208(4449):1269-71. PubMed PMID: 7375937. 4: Heiny JA, Vergara J. Optical signals from surface and T system membranes in skeletal muscle fibers. Experiments with the potentiometric dye NK2367. J Gen Physiol. 1982 Aug;80(2):203-30. PubMed PMID: 6981683; PubMed Central PMCID: PMC2228674. 5: Blasdel GG, Salama G. Voltage-sensitive dyes reveal a modular organization in monkey striate cortex. Nature. 1986 Jun 5-11;321(6070):579-85. PubMed PMID: 3713842. 6: Ashcroft FM, Heiny JA, Vergara J. Inward rectification in the transverse tubular system of frog skeletal muscle studied with potentiometric dyes. J Physiol. 1985 Feb;359:269-91. PubMed PMID: 3873536; PubMed Central PMCID: PMC1193375. 7: Konnerth A, Orkand PM, Orkand RK. Optical recording of electrical activity from axons and glia of frog optic nerve: potentiometric dye responses and morphometrics. Glia. 1988;1(3):225-32. PubMed PMID: 2852172. 8: Ross WN, Krauthamer V. Optical measurements of potential changes in axons and processes of neurons of a barnacle ganglion. J Neurosci. 1984 Mar;4(3):659-72. PubMed PMID: 6707730. 9: Salzberg BM, Obaid AL, Bezanilla F. Microsecond response of a voltage-sensitive merocyanine dye: fast voltage-clamp measurements on squid giant axon. Jpn J Physiol. 1993;43 Suppl 1:S37-41. PubMed PMID: 8271515. 10: Nakajima S, Gilai A. Action potentials of isolated single muscle fibers recorded by potential-sensitive dyes. J Gen Physiol. 1980 Dec;76(6):729-50. PubMed PMID: 10822501; PubMed Central PMCID: PMC2228611. 11: Heiny JA, Vergara J. Dichroic behavior of the absorbance signals from dyes NK2367 and WW375 in skeletal muscle fibers. J Gen Physiol. 1984 Nov;84(5):805-37. PubMed PMID: 6334719; PubMed Central PMCID: PMC2228757. 12: Konnerth A, Orkand RK. Voltage-sensitive dyes measure potential changes in axons and glia of the frog optic nerve. Neurosci Lett. 1986 May 6;66(1):49-54. PubMed PMID: 3487054. 13: Sakai T, Hirota A, Komuro H, Fujii S, Kamino K. Optical recording of membrane potential responses from early embryonic chick ganglia using voltage-sensitive dyes. Brain Res. 1985 Jan;349(1-2):39-51. PubMed PMID: 3872700. 14: Fujishiro N, Kern RE, Kawata H. Wavelength dependence of the optically recorded action potentials in guinea pig atrial muscles. Comp Biochem Physiol A Mol Integr Physiol. 1999 Feb;122(2):235-40. PubMed PMID: 10327619. 15: Sakai T. Wavelength dependence of optical action potentials in the isolated rat atrium. Jpn J Physiol. 2005 Dec;55(6):389-93. Epub 2005 Nov 16. PubMed PMID: 16285889.