MedKoo Cat#: 130276 | Name: CDIBA

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CDIBA is an inhibitor of cytosolic phospholipase A2 (cPLA(2)) and has been used to study the effects of cPLA(2) on tumor angiogenesis.

Chemical Structure

CDIBA
CAS# 479422-22-5

Theoretical Analysis

MedKoo Cat#: 130276

Name: CDIBA

CAS#: 479422-22-5

Chemical Formula: C31H26ClNO3

Exact Mass: 495.1601

Molecular Weight: 496.00

Elemental Analysis: C, 75.07; H, 5.28; Cl, 7.15; N, 2.82; O, 9.68

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CDIBA; Cdiba
IUPAC/Chemical Name
4-(2-(1-benzhydryl-5-chloro-2-methyl-1H-indol-3-yl)ethoxy)benzoic acid
InChi Key
WCJGWNYPOLQBKZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C31H26ClNO3/c1-21-27(18-19-36-26-15-12-24(13-16-26)31(34)35)28-20-25(32)14-17-29(28)33(21)30(22-8-4-2-5-9-22)23-10-6-3-7-11-23/h2-17,20,30H,18-19H2,1H3,(H,34,35)
SMILES Code
O=C(O)C1=CC=C(OCCC2=C(C)N(C(C3=CC=CC=C3)C4=CC=CC=C4)C5=C2C=C(Cl)C=C5)C=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 496.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Lee JH, Kim S, Jin MS, Kim YC. Discovery of substituted indole derivatives as allosteric inhibitors of m6 A-RNA methyltransferase, METTL3-14 complex. Drug Dev Res. 2022 May;83(3):783-799. doi: 10.1002/ddr.21910. Epub 2022 Jan 18. PMID: 35040501. 2. Linkous AG, Yazlovitskaya EM, Hallahan DE. Cytosolic phospholipase A2 and lysophospholipids in tumor angiogenesis. J Natl Cancer Inst. 2010 Sep 22;102(18):1398-412. doi: 10.1093/jnci/djq290. Epub 2010 Aug 20. PMID: 20729478; PMCID: PMC2943523. 3. Supinski GS, Alimov AP, Wang L, Song XH, Callahan LA. Calcium-dependent phospholipase A2 modulates infection-induced diaphragm dysfunction. Am J Physiol Lung Cell Mol Physiol. 2016 May 15;310(10):L975-84. doi: 10.1152/ajplung.00312.2015. Epub 2016 Mar 11. PMID: 26968769; PMCID: PMC4896095. 4. Zhou XL, Wei XJ, Li SP, Liu RN, Yu MX, Zhao Y. Interactions between Cytosolic Phospholipase A2 Activation and Mitochondrial Reactive Oxygen Species Production in the Development of Ventilator-Induced Diaphragm Dysfunction. Oxid Med Cell Longev. 2019 Apr 18;2019:2561929. doi: 10.1155/2019/2561929. PMID: 31178955; PMCID: PMC6501131.