VU0529331 | CAS# 1286725-49-2 | GIRK Channel Activator

MedKoo Cat#: 564862 | Name: VU0529331

Description:

WARNING: This product is for research use only, not for human or veterinary use.

VU0529331 is the first synthetic activator of homomeric G protein-gated, inwardly-rectifying, potassium (GIRK) channels.

Chemical Structure

VU0529331

CAS#1286725-49-2

Theoretical Analysis

MedKoo Cat#: 564862

Name: VU0529331

CAS#: 1286725-49-2

Chemical Formula: C22H20N6O

Exact Mass: 384.1699

Molecular Weight: 384.44

Elemental Analysis: C, 68.73; H, 5.24; N, 21.86; O, 4.16

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

VU-0529331; VU 0529331; VU0529331

IUPAC/Chemical Name

(2-(3,4-Dimethylphenyl)-3-(1H-pyrrol-1-yl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl)(pyrazin-2-yl)methanone

InChi Key

KKICJSSCAYMJOA-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H20N6O/c1-15-5-6-17(11-16(15)2)28-21(26-9-3-4-10-26)18-13-27(14-20(18)25-28)22(29)19-12-23-7-8-24-19/h3-12H,13-14H2,1-2H3

SMILES Code

O=C(N1CC2=NN(C3=CC=C(C)C(C)=C3)C(N4C=CC=C4)=C2C1)C5=NC=CN=C5

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 384.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kozek KA, Du Y, Sharma S, Prael FJ 3rd, Spitznagel BD, Kharade SV, Denton JS, Hopkins CR, Weaver CD. Discovery and Characterization of VU0529331, a Synthetic Small-Molecule Activator of Homomeric G Protein-Gated, Inwardly Rectifying, Potassium (GIRK) Channels. ACS Chem Neurosci. 2018 Sep 13. doi: 10.1021/acschemneuro.8b00287. [Epub ahead of print] PubMed PMID: 30136838.