Wogonoside | CAS#51059-44-0 | antifungal

MedKoo Cat#: 584640 | Name: Wogonoside

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Wogonoside is a flavonoid glycoside derived from the root of Scutellaria baicalensis Georgi, known for its anti-inflammatory, anti-angiogenic, and anticancer properties. In colon cancer cells, wogonoside inhibits cell growth, induces apoptosis, and promotes mitochondrial-mediated autophagy by modulating the PI3K/Akt/mTOR/p70S6K signaling pathway. Additionally, it has been reported to suppress tumor growth and metastasis in endometrial cancer.

Chemical Structure

Wogonoside

CAS#51059-44-0

Theoretical Analysis

MedKoo Cat#: 584640

Name: Wogonoside

CAS#: 51059-44-0

Chemical Formula: C22H20O11

Exact Mass: 460.1006

Molecular Weight: 460.39

Elemental Analysis: C, 57.40; H, 4.38; O, 38.23

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 350.00
25mg	USD 600.00
100mg	USD 1,000.00

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Related CAS #

No Data

Synonym

Wogonoside; Oroxindin

IUPAC/Chemical Name

5,7-Dihydroxy-8-methoxyflavone 7-O-beta-D-Glucuronide

InChi Key

LNOHXHDWGCMVCO-NTKSAMNMSA-N

InChi Code

InChI=1S/C22H20O11/c1-30-18-13(32-22-17(27)15(25)16(26)20(33-22)21(28)29)8-11(24)14-10(23)7-12(31-19(14)18)9-5-3-2-4-6-9/h2-8,15-17,20,22,24-27H,1H3,(H,28,29)/t15-,16-,17+,20-,22+/m0/s1

SMILES Code

O=C1C=C(C2=CC=CC=C2)OC3=C1C(O)=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](C(O)=O)O4)O)O)O)=C3OC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 460.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Gong Z, Yang H, Gao L, Liu Y, Chu Q, Luo C, Kang L, Zhai H, Xu Q, Wu W, Li N, Li R. Mechanisms of wogonoside in the treatment of atherosclerosis based on network pharmacology, molecular docking, and experimental validation. BMC Complement Med Ther. 2025 Jan 27;25(1):28. doi: 10.1186/s12906-025-04760-x. PMID: 39871254; PMCID: PMC11770944. 2: Li X, Zhao S, Xie J, Li M, Tong S, Ma J, Yang R, Zhao Q, Zhang J, Xu A. Targeting the NF-κB p65-MMP28 axis: Wogonoside as a novel therapeutic agent for attenuating podocyte injury in diabetic nephropathy. Phytomedicine. 2025 Jan 24;138:156406. doi: 10.1016/j.phymed.2025.156406. Epub ahead of print. PMID: 39862792. 3: Zhu S, Sun K, Liu S, Wang Q, Fan J, Zhao XE, Xu G. Fluorescent distinguishing flavonoid glycosides against aglycones based on the selective recognization of boric acid-functional Eu(III)-organic framework. Talanta. 2025 Jan 7;286:127559. doi: 10.1016/j.talanta.2025.127559. Epub ahead of print. PMID: 39798417. 4: Grzelka K, Matkowski A, Chodaczek G, Jaśpińska J, Pawlikowska-Bartosz A, Słupski W, Lechniak D, Szumacher-Strabel M, Olorunlowu S, Szulc K, Cieślak A, Ślusarczyk S. Pulsed Electric Field (PEF) Treatment Results in Growth Promotion, Main Flavonoids Extraction, and Phytochemical Profile Modulation of Scutellaria baicalensis Georgi Roots. Int J Mol Sci. 2024 Dec 26;26(1):100. doi: 10.3390/ijms26010100. PMID: 39795960; PMCID: PMC11719946. 5: Ślusarczyk S, Grzelka K, Jaśpińska J, Pawlikowska-Bartosz A, Pecio Ł, Stafiniak M, Rahimmalek M, Słupski W, Cieślak A, Matkowski A. Changes in Growth and Metabolic Profile of Scutellaria baicalensis Georgi in Response to Sodium Chloride. Biology (Basel). 2024 Dec 17;13(12):1058. doi: 10.3390/biology13121058. PMID: 39765725; PMCID: PMC11673518. 6: Liu Y, Zhang Z, Li X, Hu Q, Jiang Z, Lv J, Xue J, Wang D, Cao J, Li L, Ou X, Zhu L, Liu Z, Su T. Wogonin effects on the efflux transporters BCRP and MRP2, explain its effectiveness in ulcerative colitis: Implications for metabolic and transport interactions. Pharmacol Res. 2024 Dec 31;212:107570. doi: 10.1016/j.phrs.2024.107570. Epub ahead of print. PMID: 39746499. 7: Ma J, Zhang J, Xie L, Ye J, Zhou L, Yu D, Wang QW. Light quality regulates growth and flavonoid content in a widespread forest understorey medicinal species Scutellaria Baicalensis Georgi. Front Plant Sci. 2024 Dec 16;15:1488649. doi: 10.3389/fpls.2024.1488649. PMID: 39737373; PMCID: PMC11683125. 8: Wan C, Sun S, Han Y, Du Y, Li X, Zhang L, Yang Y, Hao J, Wu Y. Integrating lipid metabolomics, serum medicinal chemistry, network pharmacology and experimental validation to explore the mechanism of Sanmiao wan in the treatment of rheumatoid arthritis. J Ethnopharmacol. 2025 Jan 31;340:119295. doi: 10.1016/j.jep.2024.119295. Epub 2024 Dec 27. PMID: 39733801. 9: Shao Y, Li S, Chen X, Zhang J, Jianaerbieke H, Chen G, Wang X, Song J. Characteristic Polyphenols in 15 Varieties of Chinese Jujubes Based on Metabolomics. Metabolites. 2024 Nov 28;14(12):661. doi: 10.3390/metabo14120661. PMID: 39728442; PMCID: PMC11676182. 10: Yang Y, Liu Y, Cheng Y, He H, Liang A, Pan Z, Liu Y, Chen Z. Multi-omics and experimental analysis unveil the key components in Scutellaria baicalensis Georgi to alleviate hepatic fibrosis via regulating cPLA2-mediated arachidonic acid metabolism. J Transl Med. 2024 Dec 23;22(1):1138. doi: 10.1186/s12967-024-05955-5. PMID: 39716274; PMCID: PMC11665060. 11: Li J, Zhuang Y, Fan G, Wang S, Yan E, Guo J, Zhang C, Jiang S. Impact of baicalin and components of Scutellaria baicalensis on renal fibrosis of diabetic kidney disease. Front Pharmacol. 2024 Dec 6;15:1480626. doi: 10.3389/fphar.2024.1480626. PMID: 39712489; PMCID: PMC11658968. 12: Li L, Zhang W, Sun C, Chai Z, Wang K, Zhou Q, Wang X. Scutellariae Radix Ameliorates Prenatal Stress Induced Anxiety-like and Depression-like Behavior in the Offspring via Reversing HPA Axis Hyperfunction and Ameliorating Neurodevelopmental Dysfunction. Dev Neurosci. 2024 Dec 19:1-27. doi: 10.1159/000543152. Epub ahead of print. PMID: 39701046. 13: Wang X, Xie Y, Bayoude A, Zhang B, Yu B. Discovering the Q-marker of scutellaria baicalensis against viral pneumonia integrated chemical profile identification, pharmacokinetic, metabolomics and network pharmacology. J Ethnopharmacol. 2025 Jan 31;340:119232. doi: 10.1016/j.jep.2024.119232. Epub 2024 Dec 9. PMID: 39662860. 14: Zhang T, Zhang C, Wang W, Hu S, Tian Q, Li Y, Cui L, Li L, Wang Z, Cao X, Wang D. Effects of drought stress on the secondary metabolism of Scutellaria baicalensis Georgi and the function of SbWRKY34 in drought resistance. Plant Physiol Biochem. 2024 Nov 29;219:109362. doi: 10.1016/j.plaphy.2024.109362. Epub ahead of print. PMID: 39642440. 15: Correction. FEBS Open Bio. 2024 Dec;14(12):2118. doi: 10.1002/2211-5463.13928. Epub 2024 Nov 21. Erratum for: FEBS Open Bio. 2023 Apr;13(4):796. doi: 10.1002/2211-5463.13584. PMID: 39569529; PMCID: PMC11609577. 16: Xie J, Lin H, Jin F, Luo Y, Yang P, Song J, Yao W, Lin W, Yuan D, Zuo A, Sun J, Wang M. Jia Wei Qingxin Lotus Seed Drink ameliorates epithelial mesenchymal transition injury in diabetic kidney disease via inhibition of JMJD1C/SP1/ZEB1 signaling pathway. Phytomedicine. 2024 Dec;135:156142. doi: 10.1016/j.phymed.2024.156142. Epub 2024 Oct 9. PMID: 39541663. 17: Yang J, Lu X, Hu S, Yang X, Cao X. microRNA858 represses the transcription factor gene SbMYB47 and regulates flavonoid biosynthesis in Scutellaria baicalensis. Plant Physiol. 2024 Dec 23;197(1):kiae607. doi: 10.1093/plphys/kiae607. PMID: 39520698. 18: Ma W, Liu T, Ogaji OD, Li J, Du K, Chang Y. Recent advances in Scutellariae radix: A comprehensive review on ethnobotanical uses, processing, phytochemistry, pharmacological effects, quality control and influence factors of biosynthesis. Heliyon. 2024 Aug 20;10(16):e36146. doi: 10.1016/j.heliyon.2024.e36146. PMID: 39262990; PMCID: PMC11388511. 19: Tang B, Xie L, Wang Y, Shi Y, Kan W, Feng B, Lin C, Xu Z, Zhu W, Li J, Zhang X, Tian X, Zang Y. Exploratory research on the effective chemical basis of tanreqing injection for treating acute lung injury: In vivo, in vitro and in silico. J Ethnopharmacol. 2025 Jan 30;337(Pt 1):118780. doi: 10.1016/j.jep.2024.118780. Epub 2024 Sep 10. PMID: 39260706. 20: Liu Y, Jia Z, Wang Y, Song Y, Yan L, Zhang C. Exploring the mechanisms of Huangqin Qingfei Decoction on acute lung injury by LC-MS combined network pharmacology analysis. Phytomedicine. 2024 Nov;134:155979. doi: 10.1016/j.phymed.2024.155979. Epub 2024 Aug 22. PMID: 39208658.