Saringosterol | CAS# 6901-60-6 | LXRβ Agonist

MedKoo Cat#: 564847 | Name: Saringosterol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Saringosterol, also known as Saningosterol and Cystosphaerol, is a selective LXRβ agonist. Saringosterol is racmic at the 24-position.

Chemical Structure

Saringosterol

CAS#6901-60-6 (racemic)

Theoretical Analysis

MedKoo Cat#: 564847

Name: Saringosterol

CAS#: 6901-60-6 (racemic)

Chemical Formula: C29H48O2

Exact Mass: 428.3654

Molecular Weight: 428.70

Elemental Analysis: C, 81.25; H, 11.29; O, 7.46

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

6901-60-6 (racemic) 87859-98-1 (24S-isomer) 87859-99-2 (24R-isomer)

Synonym

Saningosterol; Saringosterol; Seringosterol; Cystosphaerol;

IUPAC/Chemical Name

(3S,8S,9S,10R,13R,14S,17R)-17-((2R)-5-hydroxy-5-isopropylhept-6-en-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol

InChi Key

OPGVEUGCNGNPSX-SVSQYMGHSA-N

InChi Code

InChI=1S/C29H48O2/c1-7-29(31,19(2)3)17-12-20(4)24-10-11-25-23-9-8-21-18-22(30)13-15-27(21,5)26(23)14-16-28(24,25)6/h7-8,19-20,22-26,30-31H,1,9-18H2,2-6H3/t20-,22+,23+,24-,25+,26+,27+,28-,29?/m1/s1

SMILES Code

O[C@H]1CC[C@]2(C)[C@@]3([H])CC[C@]4(C)[C@@H]([C@@H](CCC(C(C)C)(C=C)O)C)CC[C@@]4([H])[C@]3([H])CC=C2C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 428.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Chen Z, Liu J, Fu Z, Ye C, Zhang R, Song Y, Zhang Y, Li H, Ying H, Liu H. 24(S)-Saringosterol from edible marine seaweed Sargassum fusiforme is a novel selective LXRβ agonist. J Agric Food Chem. 2014 Jul 2;62(26):6130-7. doi: 10.1021/jf500083r. Epub 2014 Jun 20. PubMed PMID: 24927286. 2: Castro Navas FF, Giorgi G, Maggioni D, Pacciarini M, Russo V, Marinozzi M. C24-hydroxylated stigmastane derivatives as Liver X Receptor agonists. Chem Phys Lipids. 2018 May;212:44-50. doi: 10.1016/j.chemphyslip.2018.01.005. Epub 2018 Jan 17. PubMed PMID: 29352964. 3: Feng MT, Wang T, Liu AH, Li J, Yao LG, Wang B, Guo YW, Mao SC. PTP1B inhibitory and cytotoxic C-24 epimers of Δ(28)-24-hydroxy stigmastane-type steroids from the brown alga Dictyopteris undulata Holmes. Phytochemistry. 2018 Feb;146:25-35. doi: 10.1016/j.phytochem.2017.11.013. Epub 2017 Dec 22. PubMed PMID: 29207320.