MedKoo Cat#: 573344 | Name: AWD 122-60

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AWD 122-60 is a cardiotonic bipyridine that inhibits adenosine triphosphate-sensitive potassium channels of mouse skeletal muscle.

Chemical Structure

AWD 122-60
AWD 122-60
CAS#108610-89-5

Theoretical Analysis

MedKoo Cat#: 573344

Name: AWD 122-60

CAS#: 108610-89-5

Chemical Formula: C18H23N5

Exact Mass: 309.1953

Molecular Weight: 309.42

Elemental Analysis: C, 69.87; H, 7.49; N, 22.63

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
AWD 122-60, AWD-122-60, AWD 12260, AWD12260
IUPAC/Chemical Name
(3,4'-Bipyridine)-5-carbonitrile, 6-((3-(diethylamino)propyl)amino)-
InChi Key
PGTGATAQGNXSIO-UHFFFAOYSA-N
InChi Code
1S/C18H23N5/c1-3-23(4-2)11-5-8-21-18-16(13-19)12-17(14-22-18)15-6-9-20-10-7-15/h6-7,9-10,12,14H,3-5,8,11H2,1-2H3,(H,21,22)
SMILES Code
CCN(CC)CCCNc1c(cc(cn1)c2ccncc2)C#N
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 309.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bodewei R, Hehl S, Neumcke B. The cardiotonic bipyridine AWD 122-60 inhibits adenosine triphosphate-sensitive potassium channels of mouse skeletal muscle. Naunyn Schmiedebergs Arch Pharmacol. 1992 May;345(5):570-7. PubMed PMID: 1528274. 2: Reck G, Hagen V, Labes D. [Potential cardiotonics. 13. Crystal structure, charge distribution and molecular electrostatic potential of 3-cyano-2-(3-diethyl-aminopropylamino)-5-(4-pyridinyl)pyridine (AWD 122-60)]. Pharmazie. 1992 Mar;47(3):192-4. German. PubMed PMID: 1615024.