Synonym
MDG548; MDG 548; MDG-548;
IUPAC/Chemical Name
5-(4-(benzyloxy)-3-chlorobenzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
InChi Key
WJNBKDZARWFFKR-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H13ClN2O3S/c19-14-9-12(8-13-16(22)20-18(25)21-17(13)23)6-7-15(14)24-10-11-4-2-1-3-5-11/h1-9H,10H2,(H2,20,21,22,23,25)
SMILES Code
O=C(/C(C(N1)=O)=C/C2=CC=C(OCC3=CC=CC=C3)C(Cl)=C2)NC1=S
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
372.82
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2: Xu Z, Meng SH, Bai JG, Sun C, Zhao LL, Tang RF, Yin ZL, Ji JW, Yang W, Ma GJ. C/EBPα Regulates FOXC1 to Modulate Tumor Growth by Interacting with PPARγ in Hepatocellular Carcinoma. Curr Cancer Drug Targets. 2020;20(1):59-66. doi: 10.2174/1568009619666190912161003. PMID: 31512996.
3: Lecca D, Janda E, Mulas G, Diana A, Martino C, Angius F, Spolitu S, Casu MA, Simbula G, Boi L, Batetta B, Spiga S, Carta AR. Boosting phagocytosis and anti- inflammatory phenotype in microglia mediates neuroprotection by PPARγ agonist MDG548 in Parkinson's disease models. Br J Pharmacol. 2018 Aug;175(16):3298-3314. doi: 10.1111/bph.14214. Epub 2018 Jul 12. PMID: 29570770; PMCID: PMC6057897.
4: Lecca D, Nevin DK, Mulas G, Casu MA, Diana A, Rossi D, Sacchetti G, Fayne D, Carta AR. Neuroprotective and anti-inflammatory properties of a novel non- thiazolidinedione PPARγ agonist in vitro and in MPTP-treated mice. Neuroscience. 2015 Aug 27;302:23-35. doi: 10.1016/j.neuroscience.2015.04.026. Epub 2015 Apr 20. Erratum in: Neuroscience. 2016 Dec 17;339:678. Fayne D [added]. PMID: 25907448.
