MedKoo Cat#: 564832 | Name: JVW-1009

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JVW-1009 is a selective modulator of sigma 2 receptor which acts neuroprotective in a C. elegans model of amyloid precursor protein-mediated neurodegeneration.

Chemical Structure

JVW-1009
JVW-1009
CAS#2089059-30-1

Theoretical Analysis

MedKoo Cat#: 564832

Name: JVW-1009

CAS#: 2089059-30-1

Chemical Formula: C24H24N2

Exact Mass: 340.1939

Molecular Weight: 340.47

Elemental Analysis: C, 84.67; H, 7.11; N, 8.23

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
JVW1009; JVW 1009; JVW-1009
IUPAC/Chemical Name
(1S,8R)-(9-Benzyl-9-aza-tricyclo[6.3.1.02,7]dodeca-2,4,6-trien-5-yl)-phenyl-amine
InChi Key
PGEJIDHRKJUIDN-YADARESESA-N
InChi Code
InChI=1S/C24H24N2/c1-3-7-18(8-4-1)17-26-14-13-19-15-24(26)23-16-21(11-12-22(19)23)25-20-9-5-2-6-10-20/h1-12,16,19,24-25H,13-15,17H2/t19-,24+/m0/s1
SMILES Code
[H][C@]1(C2)C3=CC=C(NC4=CC=CC=C4)C=C3[C@]2([H])N(CC5=CC=CC=C5)CC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 340.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yi B, Sahn JJ, Ardestani PM, Evans AK, Scott LL, Chan JZ, Iyer S, Crisp A, Zuniga G, Pierce JT, Martin SF, Shamloo M. Small molecule modulator of sigma 2 receptor is neuroprotective and reduces cognitive deficits and neuroinflammation in experimental models of Alzheimer's disease. J Neurochem. 2017 Feb;140(4):561-575. doi: 10.1111/jnc.13917. PubMed PMID: 27926996; PubMed Central PMCID: PMC5312682.