VU0409106 is a selective negative allosteric modulator of mGlu5 receptors, with nanomolar potency. It inhibits receptor activation by binding to an allosteric site, distinct from the glutamate binding site. This compound is used in preclinical models of neuropsychiatric and neurological disorders, showing potential in conditions like Parkinson’s and schizophrenia, and demonstrates good blood-brain barrier penetration. Its action reduces mGlu5-mediated signaling without fully blocking basal receptor activity.
MedKoo Cat#: 525254
Name: VU0409106
CAS#: 1276617-62-9
Chemical Formula: C15H11FN4O2S
Exact Mass: 330.0587
Molecular Weight: 330.34
Elemental Analysis: C, 54.54; H, 3.36; F, 5.75; N, 16.96; O, 9.69; S, 9.71
The following data is based on the product molecular weight 330.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
