BH3I-2 | Apoptosis Inducer

MedKoo Cat#: 564817 | Name: BH3I-2

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BH3I-2 is a cell-permeable apoptosis inducer which specifically prevents BH3 domain-mediated interactions between pro-apoptotic and anti-apoptotic members of the Bcl-2 family.

Chemical Structure

BH3I-2

CAS#NONE

Theoretical Analysis

MedKoo Cat#: 564817

Name: BH3I-2

CAS#: NONE

Chemical Formula: C19H11BrCl3NO4S

Exact Mass: 532.8658

Molecular Weight: 535.61

Elemental Analysis: C, 42.61; H, 2.07; Br, 14.92; Cl, 19.86; N, 2.62; O, 11.95; S, 5.99

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

BH3I2; BH3I 2; BH3I-2

IUPAC/Chemical Name

3-Bromo-5-chloro-N-(2-chloro-5-((4-chlorophenyl)sulfonyl)phenyl)-2-hydroxybenzamide

InChi Key

YOLBUKIMKCWMFK-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H11BrCl3NO4S/c20-15-8-11(22)7-14(18(15)25)19(26)24-17-9-13(5-6-16(17)23)29(27,28)12-3-1-10(21)2-4-12/h1-9,25H,(H,24,26)

SMILES Code

O=C(NC1=CC(S(=O)(C2=CC=C(Cl)C=C2)=O)=CC=C1Cl)C3=CC(Cl)=CC(Br)=C3O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 535.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Füllbeck M, Gebhardt N, Hossbach J, Daniel PT, Preissner R. Computer-assisted identification of small-molecule Bcl-2 modulators. Comput Biol Chem. 2009 Dec;33(6):451-6. doi: 10.1016/j.compbiolchem.2009.10.001. Epub 2009 Oct 12. PubMed PMID: 19889579.