ASP7657 | CAS# 1196045-28-9 | EP4 Receptor Antagonist

MedKoo Cat#: 564816 | Name: ASP7657

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

ASP7657 is a novel, potent, and selective prostaglandin EP4 receptor antagonist.

Chemical Structure

ASP7657

CAS#1196045-28-9

Theoretical Analysis

MedKoo Cat#: 564816

Name: ASP7657

CAS#: 1196045-28-9

Chemical Formula: C28H26F3N3O3

Exact Mass: 509.1900

Molecular Weight: 509.53

Elemental Analysis: C, 66.00; H, 5.14; F, 11.19; N, 8.25; O, 9.42

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 575.00	2 Weeks
10mg	USD 1,050.00	2 Weeks

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Related CAS #

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Synonym

ASP-7657; ASP 7657; ASP7657

IUPAC/Chemical Name

trans-4-[[[[1-(2-quinolinylmethyl)-5-(trifluoromethyl)-1H-indol-7-yl]carbonyl]amino]methyl]-cyclohexanecarboxylic acid

InChi Key

HBDTYYZZYCVTIJ-UAPYVXQJSA-N

InChi Code

InChI=1S/C28H26F3N3O3/c29-28(30,31)21-13-20-11-12-34(16-22-10-9-18-3-1-2-4-24(18)33-22)25(20)23(14-21)26(35)32-15-17-5-7-19(8-6-17)27(36)37/h1-4,9-14,17,19H,5-8,15-16H2,(H,32,35)(H,36,37)/t17-,19-

SMILES Code

O=C([C@H]1CC[C@H](CNC(C2=CC(C(F)(F)F)=CC3=C2N(CC4=NC5=CC=CC=C5C=C4)C=C3)=O)CC1)O

Appearance

Solid powder

Purity

≥95% (mixture of isomers)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 509.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Mizukami K, Yoshida H, Nozawa E, Wada K, Ugawa T. Renoprotective effects of the novel prostaglandin EP4 receptor-selective antagonist ASP7657 in 5/6 nephrectomized chronic kidney disease rats. Naunyn Schmiedebergs Arch Pharmacol. 2018 Dec 15. doi: 10.1007/s00210-018-01600-3. [Epub ahead of print] PubMed PMID: 30554341. 2: Mizukami K, Kamada H, Yoshida H, Ishii I, Nozawa E, Wada K, Ugawa T. Pharmacological properties of ASP7657, a novel, potent, and selective prostaglandin EP4 receptor antagonist. Naunyn Schmiedebergs Arch Pharmacol. 2018 Dec;391(12):1319-1326. doi: 10.1007/s00210-018-1545-x. Epub 2018 Aug 3. PubMed PMID: 30076448.