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MedKoo Cat#: 573482 | Name: Agrimonolide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Agrimonolide is an anti-inflammatory that works through down-regulation of COX-2/iNOS and inactivation of NF-κB in lipopolysaccharide-stimulated macrophages. Agrimonolide has also been shown to induce HO-1 expression in HepG2 cells through Nrf2-transduction and p38 inactivation.

Chemical Structure

Agrimonolide
Agrimonolide
CAS#21499-24-1

Theoretical Analysis

MedKoo Cat#: 573482

Name: Agrimonolide

CAS#: 21499-24-1

Chemical Formula: C18H18O5

Exact Mass: 314.1154

Molecular Weight: 314.34

Elemental Analysis: C, 68.78; H, 5.77; O, 25.45

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Agrimonolide
IUPAC/Chemical Name
3,4-Dihydro-6,8-dihydroxy-3-(2-(4-methoxyphenyl)ethyl)-1H-2-benzopyran-1-one
InChi Key
TYFJTEPDESMEHE-HNNXBMFYSA-N
InChi Code
1S/C18H18O5/c1-22-14-5-2-11(3-6-14)4-7-15-9-12-8-13(19)10-16(20)17(12)18(21)23-15/h2-3,5-6,8,10,15,19-20H,4,7,9H2,1H3/t15-/m0/s1
SMILES Code
C1[C@@H](OC(c2c1cc(cc2O)O)=O)CCc1ccc(cc1)OC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 314.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chen L, Teng H, Zhang KY, Skalicka-Woźniak K, Georgiev MI, Xiao J. Agrimonolide and Desmethylagrimonolide Induced HO-1 Expression in HepG2 Cells through Nrf2-Transduction and p38 Inactivation. Front Pharmacol. 2017 Jan 11;7:513. doi: 10.3389/fphar.2016.00513. eCollection 2016. PubMed PMID: 28119605; PubMed Central PMCID: PMC5223292. 2: Teng H, Huang Q, Chen L. Inhibition of cell proliferation and triggering of apoptosis by agrimonolide through MAP kinase (ERK and p38) pathways in human gastric cancer AGS cells. Food Funct. 2016 Nov 9;7(11):4605-4613. PubMed PMID: 27747355. 3: Chen L, Teng H, Fang T, Xiao J. Agrimonolide from Agrimonia pilosa suppresses inflammatory responses through down-regulation of COX-2/iNOS and inactivation of NF-κB in lipopolysaccharide-stimulated macrophages. Phytomedicine. 2016 Jul 15;23(8):846-55. doi: 10.1016/j.phymed.2016.03.016. Epub 2016 Apr 22. PubMed PMID: 27288920.