MedKoo Cat#: 564811 | Name: MLS1082
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

MLS1082 is a positive allosteric modulator of the D1 dopamine receptor which acts at diverse binding sites.

Chemical Structure

MLS1082
CAS#883958-36-9

Theoretical Analysis

MedKoo Cat#: 564811

Name: MLS1082

CAS#: 883958-36-9

Chemical Formula: C24H23N3O2

Exact Mass: 385.1790

Molecular Weight: 385.47

Elemental Analysis: C, 74.78; H, 6.01; N, 10.90; O, 8.30

Price and Availability

Size Price Availability Quantity
5mg USD 265.00 2 weeks
25mg USD 785.00 2 weeks
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Related CAS #
No Data
Synonym
MLS-1082; MLS 1082; MLS1082
IUPAC/Chemical Name
2-Cyclohexyl-10-methyl-3-phenylpyrimido[4,5-b]quinoline-4,5(3H,10H)-dione
InChi Key
HZGMAMIIHBRAAR-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H23N3O2/c1-26-19-15-9-8-14-18(19)21(28)20-23(26)25-22(16-10-4-2-5-11-16)27(24(20)29)17-12-6-3-7-13-17/h3,6-9,12-16H,2,4-5,10-11H2,1H3
SMILES Code
O=C1N(C2=CC=CC=C2)C(C3CCCCC3)=NC(N(C)C4=C5C=CC=C4)=C1C5=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
MLS1082 is a pyrimidone-based D1-like dopamine receptor positive allosteric modulator, with an EC50 of 123 nM.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 385.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: Luderman KD, Conroy JL, Free RB, Southall N, Ferrer M, Sanchez-Soto M, Moritz AE, Willette BKA, Fyfe TJ, Jain P, Titus S, Hazelwood LA, Aubé J, Lane JR, Frankowski KJ, Sibley DR. Identification of Positive Allosteric Modulators of the D(1) Dopamine Receptor That Act at Diverse Binding Sites. Mol Pharmacol. 2018 Oct;94(4):1197-1209. doi: 10.1124/mol.118.113175. Epub 2018 Aug 1. PubMed PMID: 30068735; PubMed Central PMCID: PMC6117505.