UCN-02 is a protein kinase inhibitor that primarily targets protein kinase C (PKC) and cyclin-dependent kinases (CDKs), particularly CDK2. It inhibits these kinases by competing with ATP at the catalytic binding site, leading to disruption of cell cycle progression and induction of apoptosis in cancer cells. UCN-02 has also been shown to modulate checkpoint kinase 1 (Chk1), impairing DNA damage response and enhancing cytotoxic effects of DNA-damaging agents.
MedKoo Cat#: 564792
Name: UCN-02
CAS#: 121569-61-7
Chemical Formula: C28H26N4O4
Exact Mass: 482.1954
Molecular Weight: 482.54
Elemental Analysis: C, 69.70; H, 5.43; N, 11.61; O, 13.26
The following data is based on the product molecular weight 482.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
