UJN49930 is an inhibitor of UDP-galactose ceramide galactosyltransferase (UGT8), also known as ceramide galactosyltranferase (CGT; IC50 = 0.2 nM).1 It is selective for UGT8 over UGT1A1, -1A6, -2B7, -2B15, and -2B17 (IC50s = >10 µM for all). In vivo, UJN49930 inhibits the synthesis of galactosylceramide (GalCer) and sulfatide (SFT) in juvenile mouse brain (ED50s = <3 mg/kg for both) and adult mouse kidney when administered at doses of 3, 10, and 30 mg/kg.
MedKoo Cat#: 464827
Name: UJN49930
CAS#: 2414349-93-0
Chemical Formula: C20H22F6N4O4S
Exact Mass: 528.1266
Molecular Weight: 528.47
Elemental Analysis: C, 45.46; H, 4.20; F, 21.57; N, 10.60; O, 12.11; S, 6.07
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 30.0 | 56.77 | |
| DMSO | 30.0 | 56.77 | |
| Ethanol | 25.0 | 47.31 |
The following data is based on the product molecular weight 528.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
