ATB-429 | CAS# 915798-75-3 | Antitumor

MedKoo Cat#: 573302 | Name: ATB-429

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ATB-429 is a hydrogen sulfide-releasing derivative of mesalamine that exerts antinociceptive effects in a model of postinflammatory hypersensitivity. It may also have antitumor effects.

Chemical Structure

ATB-429

CAS#915798-75-3

Theoretical Analysis

MedKoo Cat#: 573302

Name: ATB-429

CAS#: 915798-75-3

Chemical Formula: C16H11NO3S3

Exact Mass: 360.9901

Molecular Weight: 361.45

Elemental Analysis: C, 53.17; H, 3.07; N, 3.88; O, 13.28; S, 26.61

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

ATB-429

IUPAC/Chemical Name

5-Amino-2-hydroxybenzoic acid 4-(5-thioxo-5H-(1,2)dithiol-3-yl)phenyl ester

InChi Key

IFYIEDLRMQRZEP-UHFFFAOYSA-N

InChi Code

1S/C16H11NO3S3/c17-10-3-6-14(18)12(7-10)15(19)20-11-4-1-9(2-5-11)13-8-22-23-16(13)21/h1-8,18H,17H2

SMILES Code

c1cc(ccc1c2cssc2=S)OC(=O)c3cc(ccc3O)N

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 361.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Wang C, Xia G, Liu X, Zhang R, Chai Y, Zhang J, Li X, Yang Y, Wang J, Liu M. Synthesis and antitumor activity of ATB-429 derivatives containing a nitric oxide-releasing moiety. Bioorg Med Chem Lett. 2016 May 1;26(9):2355-9. doi: 10.1016/j.bmcl.2016.03.012. Epub 2016 Mar 4. PubMed PMID: 26995527. 2: Fiorucci S, Orlandi S, Mencarelli A, Caliendo G, Santagada V, Distrutti E, Santucci L, Cirino G, Wallace JL. Enhanced activity of a hydrogen sulphide-releasing derivative of mesalamine (ATB-429) in a mouse model of colitis. Br J Pharmacol. 2007 Apr;150(8):996-1002. Epub 2007 Mar 5. PubMed PMID: 17339831; PubMed Central PMCID: PMC2013915. 3: Distrutti E, Sediari L, Mencarelli A, Renga B, Orlandi S, Russo G, Caliendo G, Santagada V, Cirino G, Wallace JL, Fiorucci S. 5-Amino-2-hydroxybenzoic acid 4-(5-thioxo-5H-[1,2]dithiol-3yl)-phenyl ester (ATB-429), a hydrogen sulfide-releasing derivative of mesalamine, exerts antinociceptive effects in a model of postinflammatory hypersensitivity. J Pharmacol Exp Ther. 2006 Oct;319(1):447-58. Epub 2006 Jul 19. PubMed PMID: 16855178.