Synonym
AG-18; AG 18; AG18; RG-50810; RG-50858; TX 825; Tyrphostin 23; Tyrphostin A23; Tyrphostin AG-18.
IUPAC/Chemical Name
2-[(3,4-dihydroxyphenyl)methylene]-propanedinitrile
InChi Key
VTJXFTPMFYAJJU-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H6N2O2/c11-5-8(6-12)3-7-1-2-9(13)10(14)4-7/h1-4,13-14H
SMILES Code
N#C/C(C#N)=C/C1=CC=C(O)C(O)=C1
Appearance
Light yellow solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
186.17
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Esther A, Iftach S, Esther P. Inhibition of Moloney murine leukemia virus replication by tyrphostins, tyrosine kinase inhibitors. FEBS Lett. 1994 Mar 14;341(1):99-103. doi: 10.1016/0014-5793(94)80248-3. PMID: 8137930.
2: Yemets A, Sheremet Y, Vissenberg K, Van Orden J, Verbelen JP, Blume YB. Effects of tyrosine kinase and phosphatase inhibitors on microtubules in Arabidopsis root cells. Cell Biol Int. 2008 Jun;32(6):630-7. doi: 10.1016/j.cellbi.2008.01.013. Epub 2008 Jan 25. PMID: 18343165.
3: Du XL, Gao Z, Lau CP, Chiu SW, Tse HF, Baumgarten CM, Li GR. Differential effects of tyrosine kinase inhibitors on volume-sensitive chloride current in human atrial myocytes: evidence for dual regulation by Src and EGFR kinases. J Gen Physiol. 2004 Apr;123(4):427-39. doi: 10.1085/jgp.200409013. Epub 2004 Mar 15. PMID: 15024039; PMCID: PMC2217456.
4: Sheremet YA, Yemets AI, Azmi A, Vissenberg K, Verbelen JP, Blume YB. Effects of tyrosine kinase and phosphatase inhibitors on mitosis progression in synchronized tobacco BY-2 cells. Tsitol Genet. 2012 Sep-Oct;46(5):3-11. PMID: 23342643.
5: Aflalo E, Iftach S, Segal S, Gazit A, Priel E. Inhibition of topoisomerase I activity by tyrphostin derivatives, protein tyrosine kinase blockers: mechanism of action. Cancer Res. 1994 Oct 1;54(19):5138-42. PMID: 7923131.
6: Seger R, Biener Y, Feinstein R, Hanoch T, Gazit A, Zick Y. Differential activation of mitogen-activated protein kinase and S6 kinase signaling pathways by 12-O-tetradecanoylphorbol-13-acetate (TPA) and insulin. Evidence for involvement of a TPA-stimulated protein-tyrosine kinase. J Biol Chem. 1995 Nov 24;270(47):28325-30. doi: 10.1074/jbc.270.47.28325. PMID: 7499332.
7: Shefler I, Seger R, Sagi-Eisenberg R. Gi-mediated activation of mitogen- activated protein kinase (MAPK) pathway by receptor mimetic basic secretagogues of connective tissue-type mast cells: bifurcation of arachidonic acid-induced release upstream of MAPK. J Pharmacol Exp Ther. 1999 Jun;289(3):1654-61. PMID: 10336565.
