ISIR-005 | 14-3-3/Gab2 Stabilizer

MedKoo Cat#: 564757 | Name: ISIR-005

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ISIR-005 is a natural stabilizer of the 14-3-3/Gab2 protein-protein interaction (PPI) interface.

Chemical Structure

ISIR-005

CAS#NONE

Theoretical Analysis

MedKoo Cat#: 564757

Name: ISIR-005

CAS#: NONE

Chemical Formula: C30H48O8

Exact Mass: 536.3349

Molecular Weight: 536.71

Elemental Analysis: C, 67.14; H, 9.01; O, 23.85

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

ISIR005; ISIR 005; ISIR-005

IUPAC/Chemical Name

(4aR,6S,7R,8R,8aS)-6-(((4R,5R,6R,6aS,9S,10aR,E)-5-Hydroxy-3-isopropyl-9-(methoxymethyl)-6,10a-dimethyl-1,2,4,5,6,6a,7,8,9,10a-decahydrodicyclopenta[a,d][8]annulen-4-yl)oxy)-2,2-dimethylhexahydropyrano[3,2-d][1,3]dioxine-7,8-diol

InChi Key

LOAPHXVWCJVEPY-XXUMMOLISA-N

InChi Code

InChI=1S/C30H48O8/c1-15(2)18-10-11-30(6)12-20-17(13-34-7)8-9-19(20)16(3)23(31)27(22(18)30)37-28-25(33)24(32)26-21(36-28)14-35-29(4,5)38-26/h12,15-17,19,21,23-28,31-33H,8-11,13-14H2,1-7H3/b20-12-/t16-,17-,19+,21-,23-,24-,25-,26-,27-,28-,30-/m1/s1

SMILES Code

O[C@@H]1[C@@H](O)[C@]2([H])OC(C)(C)OC[C@@]2([H])O[C@@H]1O[C@H]3[C@H](O)[C@H](C)[C@@](CC[C@@H]/4COC)([H])C4=C/[C@]5(C)C3=C(C(C)C)CC5

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 536.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Bier D, Bartel M, Sies K, Halbach S, Higuchi Y, Haranosono Y, Brummer T, Kato N, Ottmann C. Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface. ChemMedChem. 2016 Apr 19;11(8):911-8. doi: 10.1002/cmdc.201500484. Epub 2015 Dec 8. PubMed PMID: 26644359. 2: Kasukabe T, Honma Y, Okabe-Kado J, Higuchi Y, Kato N, Kumakura S. Combined treatment with cotylenin A and phenethyl isothiocyanate induces strong antitumor activity mainly through the induction of ferroptotic cell death in human pancreatic cancer cells. Oncol Rep. 2016 Aug;36(2):968-76. doi: 10.3892/or.2016.4867. Epub 2016 Jun 10. PubMed PMID: 27375275.