AZD-1678 is a potent CCR4 receptor antagonist. AZD-1678 targets a molecule called CCR4, which is found on immune cells and helps direct these cells to where they need to go. In kidney cancer, CCR4 is thought to drive immune cells toward the tumor cell. When this happens, the tumor causes the immune cells that are redirected toward it to become inactive or, in the worst case, aid the spread of cancer. CCR4 receptor antagonists for the treatment of allergic rhinitis.
MedKoo Cat#: 407808
Name: AZD-1678
CAS#: 942137-41-9
Chemical Formula: C11H8Cl2FN3O3S
Exact Mass: 350.9647
Molecular Weight: 352.16
Elemental Analysis: C, 37.52; H, 2.29; Cl, 20.13; F, 5.39; N, 11.93; O, 13.63; S, 9.10
The following data is based on the product molecular weight 352.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
