P 34081 | CAS# | inhibitor

MedKoo Cat#: 584751 | Name: P 34081

Description:

WARNING: This product is for research use only, not for human or veterinary use.

P 34081 rapidly blocks parasite cysteine proteinase activity in vivo.

Chemical Structure

P 34081

CAS#148504-23-8

Theoretical Analysis

MedKoo Cat#: 584751

Name: P 34081

CAS#: 148504-23-8

Chemical Formula: C26H33FN4O4

Exact Mass: 484.2486

Molecular Weight: 484.57

Elemental Analysis: C, 64.45; H, 6.86; F, 3.92; N, 11.56; O, 13.21

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

P 34081; P-34081; P34081

IUPAC/Chemical Name

Benzenepropanamide, N-(3-fluoro-2-oxo-1-(2-phenylethyl)propyl)-alpha-((((4-morpholinylmethyl)amino)carbonyl)amino)-, (S-(R*,R*))-

InChi Key

HVNUJYRAMGSGJV-GOTSBHOMSA-N

InChi Code

InChI=1S/C26H33FN4O4/c27-18-24(32)22(12-11-20-7-3-1-4-8-20)29-25(33)23(17-21-9-5-2-6-10-21)30-26(34)28-19-31-13-15-35-16-14-31/h1-10,22-23H,11-19H2,(H,29,33)(H2,28,30,34)/t22-,23-/m0/s1

SMILES Code

O=C(N[C@@H](CCC1=CC=CC=C1)C(CF)=O)[C@@H](NC(NCN2CCOCC2)=O)CC3=CC=CC=C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 484.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Perche O, Doly M, Ranchon-Cole I. Calpains are activated by light but their inhibition has no neuroprotective effect against light-damage. Exp Eye Res. 2009 Dec;89(6):989-94. doi: 10.1016/j.exer.2009.08.012. Epub 2009 Sep 1. PubMed PMID: 19729009. 2: Esser RE, Angelo RA, Murphey MD, Watts LM, Thornburg LP, Palmer JT, Talhouk JW, Smith RE. Cysteine proteinase inhibitors decrease articular cartilage and bone destruction in chronic inflammatory arthritis. Arthritis Rheum. 1994 Feb;37(2):236-47. PubMed PMID: 8129779. 3: Rosenthal PJ, Lee GK, Smith RE. Inhibition of a Plasmodium vinckei cysteine proteinase cures murine malaria. J Clin Invest. 1993 Mar;91(3):1052-6. PubMed PMID: 8450035; PubMed Central PMCID: PMC288059.